InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Idi1

Summary

InnateDB Gene

IDBG-129163.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Idi1

Gene Name

isopentenyl-diphosphate delta isomerase

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000058258

Encoded Proteins

IDBP-627224

isopentenyl-diphosphate delta isomerase

IDBP-713338

IDBP-712227

IDBP-712260

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 26938778

Mir342 is involved in a novel post-transcriptional viral defence mechanism in IFN-activated macrophages by directly targeting Srebf2, Idi1, Dhcr7 and Sc4mol of the sterol pathway.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000067064:
IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity. [provided by RefSeq, Jul 2008]
IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:8885501-8892451

Strand

Forward strand

Band

Transcripts

ENSMUST00000169314	ENSMUSP00000132780
ENSMUST00000177400	ENSMUSP00000135770
ENSMUST00000177397	ENSMUSP00000135349
ENSMUST00000176851
ENSMUST00000177447	ENSMUSP00000135861

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004452	isopentenyl-diphosphate delta-isomerase activity
GO:0016787	hydrolase activity
GO:0030145	manganese ion binding

Biological Process

GO:0006695	cholesterol biosynthetic process
GO:0008299	isoprenoid biosynthetic process
GO:0035634	response to stilbenoid
GO:0045087	innate immune response (InnateDB)
GO:0050992	dimethylallyl diphosphate biosynthetic process