Version 5.4
| Mus musculus Gene: Ntsr2 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-129335.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Ntsr2 | ||||||||
| Gene Name | neurotensin receptor 2 | ||||||||
| Synonyms | NT2R; NTRL | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Gene | ENSMUSG00000020591 | ||||||||
| Encoded Proteins |
neurotensin receptor 2
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169006:
The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 12:16653470-16660236 | ||||||||
| Strand | Forward strand | ||||||||
| Band | A1.1 | ||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||
| NETPATH | |||||||||
| REACTOME | |||||||||
| KEGG |
Neuroactive ligand-receptor interaction pathway
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| INOH | |||||||||
| PID NCI | |||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME |
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Peptide ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
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| KEGG |
Neuroactive ligand-receptor interaction pathway
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| INOH | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | P70310 | ||||||||
| TrEMBL | Q8VIF4 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 18217 | ||||||||
| UniGene | Mm.281715 | ||||||||
| RefSeq | NM_008747 XM_006515011 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS36407 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| MGI ID | MGI:108018 | ||||||||
| MGI Symbol | Ntsr2 | ||||||||
| EMBL | AB041827 AB041828 AC122228 AK158943 BC141019 U51908 | ||||||||
| GenPept | AAB17285 AAI41020 BAB79257 BAB79258 BAE34736 | ||||||||
| RNA Seq Atlas | 18217 | ||||||||