InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Drosha

Summary

InnateDB Gene

IDBG-130254.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Drosha

Gene Name

drosha, ribonuclease type III

Synonyms

1110013A17Rik; AI874853; Etohi2; Rn3; Rnasen

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022191

Encoded Proteins

IDBP-130256

drosha, ribonuclease type III

IDBP-539979

drosha, ribonuclease type III

IDBP-623274

drosha, ribonuclease type III

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113360:
Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002 [PubMed 12191433]). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003 [PubMed 14508493]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:12824815-12935290

Strand

Forward strand

Band

Transcripts

ENSMUST00000090292	ENSMUSP00000087762
ENSMUST00000141706
ENSMUST00000147647
ENSMUST00000156594
ENSMUST00000129031	ENSMUSP00000121499
ENSMUST00000150211
ENSMUST00000141010
ENSMUST00000169061	ENSMUSP00000129279

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001530	lipopolysaccharide binding
GO:0003723	RNA binding
GO:0004521	endoribonuclease activity
GO:0004525	ribonuclease III activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006396	RNA processing
GO:0010468	regulation of gene expression
GO:0010586	miRNA metabolic process
GO:0016075	rRNA catabolic process
GO:0031053	primary miRNA processing
GO:0031054	pre-miRNA processing
GO:0042254	ribosome biogenesis
GO:0050829	defense response to Gram-negative bacterium
GO:0050830	defense response to Gram-positive bacterium
GO:0090501	RNA phosphodiester bond hydrolysis
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic

Cellular Component

GO:0005730

nucleolus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000113360

View Gene Order

ENSBTAG00000017551

Not yet available

Pathways

NETPATH

REACTOME

REACT_221178

MicroRNA (miRNA) biogenesis pathway

REACT_233572

Gene Expression pathway

REACT_206535

Regulatory RNA pathways pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_12417

MicroRNA (miRNA) biogenesis pathway

REACT_71

Gene Expression pathway

REACT_12472

Regulatory RNA pathways pathway

KEGG

INOH

PID NCI

p53downstreampathway

Direct p53 effectors

Cross-References

SwissProt

Q5HZJ0

TrEMBL

Q6PAJ6 Q6PF88 Q7TMI8 Q9CTG2

UniProt Splice Variant

Entrez Gene

14000

UniGene

Mm.293142

RefSeq

NM_001130149 NM_026799 XM_006520021

OMIM

CCDS

CCDS49583

HPRD

IMGT

MGI ID

MGI:1261425

MGI Symbol

Drosha

EMBL

AK003651 AK144147 AK148640 BC055696 BC057687 BC060265 BC088999

GenPept

AAH55696 AAH57687 AAH60265 AAH88999 BAB22917 BAE25729 BAE28629

RNA Seq Atlas

14000