Version 5.4
Homo sapiens Gene: ARAP2
Summary
InnateDB Gene IDBG-13031.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARAP2
Gene Name ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000047365
Encoded Proteins
IDBP-13033
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
IDBP-482253
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
IDBP-479344
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
IDBP-809503
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:35948221-36244509
Strand Reverse strand
Band p14
Transcripts
ENST00000303965 ENSP00000302895
ENST00000512804
ENST00000503904
ENST00000508066
ENST00000511416 ENSP00000423886
ENST00000506189 ENSP00000422731
ENST00000618163 ENSP00000481036
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0032312 regulation of ARF GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037999
View Gene Order
ENSBTAG00000039922
Not yet available
Pathways
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
arf6_pathway
Arf6 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.479451 Hs.601941 Hs.629528 Hs.739008
RefSeq NM_015230 XM_005262638 XM_005262642 XM_005262643
HUGO
OMIM
CCDS CCDS3441
HPRD 09439
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca