InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Stmn2

Summary

InnateDB Gene

IDBG-130673.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stmn2

Gene Name

stathmin-like 2

Synonyms

AI159727; SCG10; Scgn10; Stmb2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027500

Encoded Proteins

IDBP-130675

stathmin-like 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104435:
This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010]
This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down\'s syndrome and Alzheimer\'s disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:8509527-8561604

Strand

Forward strand

Band

Transcripts

ENSMUST00000029002

ENSMUSP00000029002

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0007026	negative regulation of microtubule depolymerization
GO:0010976	positive regulation of neuron projection development
GO:0010977	negative regulation of neuron projection development
GO:0031110	regulation of microtubule polymerization or depolymerization
GO:0031115	negative regulation of microtubule polymerization
GO:0031117	positive regulation of microtubule depolymerization
GO:1990090	cellular response to nerve growth factor stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0030424	axon
GO:0030426	growth cone
GO:0031982	vesicle
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000104435

View Gene Order

ENSBTAG00000020099

Not yet available

Cross-References

SwissProt

P55821

TrEMBL

Q545S4

UniProt Splice Variant

Entrez Gene

20257

UniGene

Mm.400075 Mm.409993

RefSeq

NM_025285

OMIM

CCDS

CCDS17231

HPRD

IMGT

MGI ID

MGI:98241

MGI Symbol

Stmn2

EMBL

AK003659 AK149212 BC026538 CH466577 L20259 L20260 L20261 L20262 L20263

GenPept

AAH26538 BAB22921 BAE28766 EDL05200

RNA Seq Atlas

20257