Version 5.4
Homo sapiens Gene: FLVCR2
Summary
InnateDB Gene IDBG-13068.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FLVCR2
Gene Name feline leukemia virus subgroup C cellular receptor family, member 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000119686
Encoded Proteins
IDBP-13070
Feline leukemia virus subgroup C receptor-related protein 2
IDBP-601432
Feline leukemia virus subgroup C receptor-related protein 2
IDBP-602372
Feline leukemia virus subgroup C receptor-related protein 2
IDBP-586730
Feline leukemia virus subgroup C receptor-related protein 2
IDBP-602424
Feline leukemia virus subgroup C receptor-related protein 2
IDBP-583336
Feline leukemia virus subgroup C receptor-related protein 2
IDBP-599333
Feline leukemia virus subgroup C receptor-related protein 2
IDBP-590482
Feline leukemia virus subgroup C receptor-related protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the major facilitator superfamily. The encoded transmembrane protein is a calcium transporter. Unlike the related protein feline leukemia virus subgroup C receptor 1, the protein encoded by this locus does not bind to feline leukemia virus subgroup C envelope protein. The encoded protein may play a role in development of brain vascular endothelial cells, as mutations at this locus have been associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:75578617-75663214
Strand Forward strand
Band q24.3
Transcripts
ENST00000238667 ENSP00000238667
ENST00000554496
ENST00000555385
ENST00000539311 ENSP00000443439
ENST00000555058 ENSP00000451104
ENST00000553341 ENSP00000452584
ENST00000556241
ENST00000553587 ENSP00000451603
ENST00000556856 ENSP00000452468
ENST00000554580 ENSP00000451781
ENST00000555027 ENSP00000452453
ENST00000556409
ENST00000556745
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0015232 heme transporter activity
GO:0020037 heme binding
Biological Process
GO:0015886 heme transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000034258
View Gene Order
Cross-References
SwissProt
TrEMBL G3V5Q8
UniProt Splice Variant
Entrez Gene 55640
UniGene Hs.509966
RefSeq NM_001195283 NM_017791
HUGO HGNC:20105
OMIM 610865
CCDS CCDS55933 CCDS9844
HPRD 12654
IMGT
EMBL AC007182
GenPept
RNA Seq Atlas 55640

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca