InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cdh18

Summary

InnateDB Gene

IDBG-130778.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdh18

Gene Name

cadherin 18

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040420

Encoded Proteins

IDBP-623546

cadherin 18

IDBP-623550

cadherin 18

IDBP-623551

cadherin 18

IDBP-623553

cadherin 18

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145526:
This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance. [provided by RefSeq, Jul 2008]
This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:22549022-23474418

Strand

Forward strand

Band

Transcripts

ENSMUST00000040427
ENSMUST00000163361	ENSMUSP00000129170
ENSMUST00000170626
ENSMUST00000164787	ENSMUSP00000130851
ENSMUST00000165614	ENSMUSP00000128643
ENSMUST00000167623	ENSMUSP00000128011

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005509	calcium ion binding

Biological Process

GO:0007156	homophilic cell adhesion
GO:0008150	biological_process

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000145526

View Gene Order

ENSBTAG00000037844

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_19195

Adherens junctions interactions pathway

REACT_111155

Cell-Cell communication pathway

REACT_20676

Cell junction organization pathway

REACT_19331

Cell-cell junction organization pathway

REACT_214866

Cell junction organization pathway

REACT_206475

Cell-Cell communication pathway

REACT_207240

Cell-cell junction organization pathway

REACT_212282

Adherens junctions interactions pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

Q8BLB5

UniProt Splice Variant

Entrez Gene

320865

UniGene

RefSeq

NM_001081299 XM_006520094 XM_006520095 XM_006520096

OMIM

CCDS

CCDS49585

HPRD

IMGT

MGI ID

MGI:1344366

MGI Symbol

Cdh18

EMBL

AC121357 AC124467 AC133461 AC134595 AC134864 AC137875 AC157478 AC158771 AC172891 AK045672

GenPept

BAC32451

RNA Seq Atlas

320865