Version 5.4
Mus musculus Gene: Ppl
Summary
InnateDB Gene IDBG-130873.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppl
Gene Name periplakin
Synonyms AW553870
Species Mus musculus
Ensembl Gene ENSMUSG00000039457
Encoded Proteins
IDBP-130875
periplakin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118898:
The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:5086291-5132481
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000035672 ENSMUSP00000039360
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005856 cytoskeleton
GO:0019897 extrinsic component of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000118898
View Gene Order
ENSBTAG00000002178
Not yet available
Cross-References
SwissProt
TrEMBL G5E898 Q3UQD7
UniProt Splice Variant
Entrez Gene 19041
UniGene Mm.266875
RefSeq NM_008909
OMIM
CCDS CCDS27932
HPRD
IMGT
MGI ID MGI:1194898
MGI Symbol Ppl
EMBL AC124576 AC163723 AK142562 CH466521
GenPept BAE25105 EDK97278
RNA Seq Atlas 19041

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca