Version 5.4
Mus musculus Gene: Fabp5
Summary
InnateDB Gene IDBG-131127.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fabp5
Gene Name fatty acid binding protein 5, epidermal
Synonyms E-FABP; Fabpe; Klbp; mal1; PA-FABP
Species Mus musculus
Ensembl Gene ENSMUSG00000027533
Encoded Proteins
IDBP-131129
fatty acid binding protein 5, epidermal
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is part of the fatty acid binding protein family (FABP). FABPs are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands and participate in fatty acid uptake, transport, and metabolism. In humans this gene has been associated with psoriasis and type 2 diabetes. In mouse deficiency of this gene in combination with a deficiency in Fabp4 confers protection against atherosclerosis, diet-induced obesity, insulin resistance and experimental autoimmune encephalomyelitis (the mouse model for multiple sclerosis). Alternative splicing results in multiple transcript variants that encode different protein isoforms. The mouse genome contains many pseudogenes similar to this locus. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:10012548-10016607
Strand Forward strand
Band A1
Transcripts
ENSMUST00000029046 ENSMUSP00000029046
ENSMUST00000123744
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005504 fatty acid binding
GO:0005515 protein binding
Biological Process
GO:0006006 glucose metabolic process
GO:0006629 lipid metabolic process
GO:0006656 phosphatidylcholine biosynthetic process
GO:0009611 response to wounding
GO:0015758 glucose transport
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000164687
View Gene Order
ENSBTAG00000047330
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu03320
PPAR signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa03320
PPAR signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q05816
TrEMBL Q497I3
UniProt Splice Variant
Entrez Gene 16592
UniGene Mm.343864 Mm.415807 Mm.741
RefSeq NM_001272097 NM_010634
OMIM
CCDS CCDS38388
HPRD
IMGT
MGI ID MGI:101790
MGI Symbol Fabp5
EMBL AF061014 AF061015 AJ223066 AK008782 AK011551 AK167389 BC002008 BC100543 CH466577 X70100
GenPept AAC82368 AAH02008 AAI00544 BAB25890 BAB27692 BAE39479 CAA11069 CAA49703 EDL05177
RNA Seq Atlas 16592

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca