Version 5.4
Homo sapiens Gene: GJA3
Summary
InnateDB Gene IDBG-13114.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GJA3
Gene Name gap junction protein, alpha 3, 46kDa
Synonyms CTRCT14; CX46; CZP3
Species Homo sapiens
Ensembl Gene ENSG00000121743
Encoded Proteins
IDBP-13116
gap junction protein, alpha 3, 46kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a connexin and is a component of lens fiber gap junctions. Defects in this gene are a cause of zonular pulverulent cataract type 3 (CZP3). [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:20138255-20161049
Strand Reverse strand
Band q12.11
Transcripts
ENST00000241125 ENSP00000241125
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005243 gap junction channel activity
Biological Process
GO:0006810 transport
GO:0007267 cell-cell signaling
GO:0007601 visual perception
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005921 gap junction
GO:0005922 connexon complex
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000048582
View Gene Order
ENSBTAG00000020400
Not yet available
Pathways
NETPATH
REACTOME
REACT_9509
Gap junction assembly pathway
REACT_9411
Gap junction trafficking pathway
REACT_9480
Gap junction trafficking and regulation pathway
REACT_11123
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9Y6H8
TrEMBL
UniProt Splice Variant
Entrez Gene 2700
UniGene Hs.130313
RefSeq NM_021954 XM_005266353
HUGO HGNC:4277
OMIM 121015
CCDS CCDS9289
HPRD
IMGT
EMBL AF075290 AL138688 BC121137
GenPept AAD42925 AAI21138
RNA Seq Atlas 2700

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca