Version 5.4
Mus musculus Gene: Chmp4c
Summary
InnateDB Gene IDBG-131436.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Chmp4c
Gene Name charged multivesicular body protein 4C
Synonyms 2010012P02Rik; 2210015K02Rik; 2310010I16Rik; Shax3; Snf7-3
Species Mus musculus
Ensembl Gene ENSMUSG00000027536
Encoded Proteins
IDBP-131438
charged multivesicular body protein 4C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164695:
CHMP4C belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:10366907-10391005
Strand Forward strand
Band A1
Transcripts
ENSMUST00000029049 ENSMUSP00000029049
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0009838 abscission
GO:0015031 protein transport
GO:0031565 cytokinesis checkpoint
GO:0032466 negative regulation of cytokinesis
GO:0050792 regulation of viral process
GO:1902188 positive regulation of viral release from host cell
Cellular Component
GO:0005829 cytosol
GO:0030496 midbody
GO:0031902 late endosome membrane
GO:0070062 extracellular vesicular exosome
GO:0090543 Flemming body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000164695
View Gene Order
ENSBTAG00000004792
Not yet available
Pathways
NETPATH
REACTOME
REACT_209837
Membrane Trafficking pathway
REACT_198518
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
KEGG
mmu04144
Endocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_27258
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
REACT_6256
HIV Life Cycle pathway
REACT_6185
HIV Infection pathway
REACT_6359
Budding and maturation of HIV virion pathway
REACT_116125
Disease pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt Q9D7F7
TrEMBL
UniProt Splice Variant
Entrez Gene 66371
UniGene
RefSeq NM_025519
OMIM
CCDS CCDS17243
HPRD
IMGT
MGI ID MGI:1913621
MGI Symbol Chmp4c
EMBL AK009273 AK010707 AK160189 BC115983 BC117538
GenPept AAI15984 AAI17539 BAB26186 BAB27133 BAE35682
RNA Seq Atlas 66371

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca