Version 5.4
Mus musculus Gene: Ccnc
Summary
InnateDB Gene IDBG-131508.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ccnc
Gene Name cyclin C
Synonyms AI451004; AU020987; CG1C
Species Mus musculus
Ensembl Gene ENSMUSG00000028252
Encoded Proteins
IDBP-131510
cyclin C
IDBP-131516
cyclin C
IDBP-264956
cyclin C
IDBP-401331
cyclin C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112237:
The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:21727701-21759922
Strand Forward strand
Band A3
Transcripts
ENSMUST00000065928 ENSMUSP00000069076
ENSMUST00000102997 ENSMUSP00000100062
ENSMUST00000108240 ENSMUSP00000103875
ENSMUST00000120679 ENSMUSP00000113682
ENSMUST00000133597
ENSMUST00000123294
ENSMUST00000145288
ENSMUST00000133712
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005654 nucleoplasm
GO:0016591 DNA-directed RNA polymerase II, holoenzyme
GO:0016592 mediator complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000112237
View Gene Order
ENSBTAG00000015744
Not yet available
Pathways
NETPATH
REACTOME
REACT_27166
Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes pathway
REACT_217958
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_252217
Transcriptional regulation of white adipocyte differentiation pathway
REACT_200794
Mus musculus biological processes pathway
REACT_189085
Disease pathway
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_215068
Loss of Function of SMAD4 in Cancer pathway
REACT_213336
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_224217
TGFBR1 LBD Mutants in Cancer pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_196589
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_257219
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_204241
Loss of Function of TGFBR2 in Cancer pathway
REACT_199382
Signaling by NOTCH1 pathway
REACT_199410
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_216792
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_199405
Signaling by NOTCH1 in Cancer pathway
REACT_199407
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_199406
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_199409
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_199408
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_224787
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_233572
Gene Expression pathway
REACT_198602
PPARA activates gene expression pathway
REACT_188576
Developmental Biology pathway
REACT_223317
Loss of Function of TGFBR1 in Cancer pathway
REACT_196464
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_209370
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_202264
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_206529
Generic Transcription Pathway pathway
REACT_188257
Signal Transduction pathway
REACT_224802
TGFBR1 KD Mutants in Cancer pathway
REACT_212101
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_231152
Signaling by NOTCH pathway
REACT_196591
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
REACT_225428
Signaling by TGF-beta Receptor Complex pathway
REACT_226256
Loss of Function of SMAD2/3 in Cancer pathway
REACT_203903
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_120734
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
REACT_118780
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_160243
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_160254
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_111045
Developmental Biology pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_121061
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_299
Signaling by NOTCH pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_111217
Metabolism pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
REACT_221284
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_227938
Generic Transcription Pathway pathway
REACT_207951
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_220704
Signaling by NOTCH pathway
REACT_213874
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_221739
Loss of Function of TGFBR1 in Cancer pathway
REACT_217678
Signaling by TGF-beta Receptor Complex pathway
REACT_220609
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_207152
Loss of Function of SMAD4 in Cancer pathway
REACT_221028
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
REACT_209241
Loss of Function of TGFBR2 in Cancer pathway
REACT_226022
Gene Expression pathway
REACT_211655
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_220799
Transcriptional regulation of white adipocyte differentiation pathway
REACT_204419
Signaling by NOTCH1 in Cancer pathway
REACT_211897
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_214353
Signal Transduction pathway
REACT_225370
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_211138
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_225877
Signaling by NOTCH1 pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_219139
Metabolism pathway
REACT_223827
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_227244
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_225248
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_207237
PPARA activates gene expression pathway
REACT_207908
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_224116
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
REACT_207832
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_204471
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_226458
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_216195
Loss of Function of SMAD2/3 in Cancer pathway
REACT_220643
TGFBR1 LBD Mutants in Cancer pathway
REACT_207087
Disease pathway
REACT_209664
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_223905
TGFBR1 KD Mutants in Cancer pathway
REACT_220844
Developmental Biology pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.278584 Mm.400278 Mm.403175
RefSeq NM_001122982 NM_001290420 NM_001290422 NM_016746 XM_006538076 XM_006538077 XM_006538078 XM_006538079 XM_006538081 XM_006538082
OMIM
CCDS CCDS17998 CCDS51127 CCDS71350
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca