Version 5.4
Mus musculus Gene: Acox2
Summary
InnateDB Gene IDBG-131877.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Acox2
Gene Name acyl-Coenzyme A oxidase 2, branched chain
Synonyms THCCox
Species Mus musculus
Ensembl Gene ENSMUSG00000021751
Encoded Proteins
IDBP-131879
acyl-Coenzyme A oxidase 2, branched chain
IDBP-623351
acyl-Coenzyme A oxidase 2, branched chain
IDBP-623353
acyl-Coenzyme A oxidase 2, branched chain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168306:
The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger syndrome, severe mental retardation, and death in children. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:8225511-8259353
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000022271 ENSMUSP00000022271
ENSMUST00000116361
ENSMUST00000164598 ENSMUSP00000126464
ENSMUST00000165169
ENSMUST00000164412
ENSMUST00000170534 ENSMUSP00000130543
ENSMUST00000171567
ENSMUST00000171175
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003995 acyl-CoA dehydrogenase activity
GO:0003997 acyl-CoA oxidase activity
GO:0005102 receptor binding
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0033791 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005777 peroxisome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000168306
View Gene Order
ENSBTAG00000004178
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_207530
Synthesis of bile acids and bile salts pathway
REACT_203193
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway
REACT_243096
Beta-oxidation of pristanoyl-CoA pathway
REACT_246750
Peroxisomal lipid metabolism pathway
REACT_229469
Bile acid and bile salt metabolism pathway
KEGG
mmu00120
Primary bile acid biosynthesis pathway
mmu03320
PPAR signaling pathway pathway
mmu04146
Peroxisome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_17017
Beta-oxidation of pristanoyl-CoA pathway
REACT_11041
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway
REACT_11054
Synthesis of bile acids and bile salts pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_16957
Peroxisomal lipid metabolism pathway
REACT_11040
Bile acid and bile salt metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa03320
PPAR signaling pathway pathway
hsa00120
Primary bile acid biosynthesis pathway
hsa04146
Peroxisome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9Q5T5
UniProt Splice Variant
Entrez Gene 93732
UniGene Mm.28700
RefSeq NM_001161667 NM_053115 XM_006518108
OMIM
CCDS CCDS36801
HPRD
IMGT
MGI ID MGI:1934852
MGI Symbol Acox2
EMBL CT025547
GenPept
RNA Seq Atlas 93732

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca