Version 5.4
Mus musculus Gene: Rnaseh1
Summary
InnateDB Gene IDBG-132054.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rnaseh1
Gene Name ribonuclease H1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000020630
Encoded Proteins
IDBP-132056
ribonuclease H1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and is necessary for DNA replication and repair. This enzyme is present in both mitochondria and nuclei, which are resulted from translation of a single mRNA with two in-frame initiation start codons. The use of the first start codon produces the mitochondrial isoform and the use of the second start codon produces the nuclear isoform. The production of the mitochondrial isoform is modulated by an upstream open reading frame (uORF) which encodes 7aa in mouse. An alternately spliced transcript variant has been found which is a candidate for nonsense-mediated mRNA decay (NMD). [provided by RefSeq, Nov 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:28649602-28659591
Strand Forward strand
Band A2
Transcripts
ENSMUST00000020959 ENSMUSP00000020959
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0004523 RNA-DNA hybrid ribonuclease activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006264 mitochondrial DNA replication
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000171865
View Gene Order
ENSBTAG00000016235
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu03030
DNA replication pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa03030
DNA replication pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9QLN8
UniProt Splice Variant
Entrez Gene 19819
UniGene
RefSeq NM_001286865 NM_011275 XM_006515018
OMIM
CCDS CCDS25852
HPRD
IMGT
MGI ID MGI:1335073
MGI Symbol Rnaseh1
EMBL AC136986
GenPept
RNA Seq Atlas 19819

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca