InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Crh

Summary

InnateDB Gene

IDBG-132673.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Crh

Gene Name

corticotropin releasing hormone

Synonyms

CRF; Gm1347

Species

Mus musculus

Ensembl Gene

ENSMUSG00000049796

Encoded Proteins

IDBP-132675

corticotropin releasing hormone

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147571:
Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Apr 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:19693401-19695396

Strand

Reverse strand

Band

Transcripts

ENSMUST00000061294

ENSMUSP00000061185

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0017045	corticotropin-releasing hormone activity
GO:0051430	corticotropin-releasing hormone receptor 1 binding
GO:0051431	corticotropin-releasing hormone receptor 2 binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0001963	synaptic transmission, dopaminergic
GO:0006704	glucocorticoid biosynthetic process
GO:0006954	inflammatory response
GO:0007565	female pregnancy
GO:0007611	learning or memory
GO:0007616	long-term memory
GO:0007631	feeding behavior
GO:0008202	steroid metabolic process
GO:0008284	positive regulation of cell proliferation
GO:0008306	associative learning
GO:0008628	hormone-mediated apoptotic signaling pathway
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0010700	negative regulation of norepinephrine secretion
GO:0010942	positive regulation of cell death
GO:0014062	regulation of serotonin secretion
GO:0016101	diterpenoid metabolic process
GO:0021854	hypothalamus development
GO:0030324	lung development
GO:0030325	adrenal gland development
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0032811	negative regulation of epinephrine secretion
GO:0033494	ferulate metabolic process
GO:0033685	negative regulation of luteinizing hormone secretion
GO:0035641	locomotory exploration behavior
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0035902	response to immobilization stress
GO:0042220	response to cocaine
GO:0042493	response to drug
GO:0043627	response to estrogen
GO:0045471	response to ethanol
GO:0045472	response to ether
GO:0045776	negative regulation of blood pressure
GO:0048265	response to pain
GO:0050801	ion homeostasis
GO:0051412	response to corticosterone
GO:0051461	positive regulation of corticotropin secretion
GO:0051464	positive regulation of cortisol secretion
GO:0051602	response to electrical stimulus
GO:0060291	long-term synaptic potentiation
GO:0060456	positive regulation of digestive system process
GO:0060548	negative regulation of cell death
GO:0070093	negative regulation of glucagon secretion
GO:0071314	cellular response to cocaine
GO:0071549	cellular response to dexamethasone stimulus
GO:0090280	positive regulation of calcium ion import
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000854	positive regulation of corticosterone secretion
GO:2000987	positive regulation of behavioral fear response