Version 5.4
Mus musculus Gene: Sema5a
Summary
InnateDB Gene IDBG-133049.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sema5a
Gene Name sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
Synonyms 5930434A13; 9130201M22Rik; AI464145; Semaf; semF
Species Mus musculus
Ensembl Gene ENSMUSG00000022231
Encoded Proteins
IDBP-133051
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112902:
This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.[provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:32244813-32696341
Strand Forward strand
Band B3.1
Transcripts
ENSMUST00000067458 ENSMUSP00000069024
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0008046 axon guidance receptor activity
GO:0035373 chondroitin sulfate proteoglycan binding
GO:0043395 heparan sulfate proteoglycan binding
GO:0045545 syndecan binding
Biological Process
GO:0001569 patterning of blood vessels
GO:0007275 multicellular organismal development
GO:0007411 axon guidance
GO:0007413 axonal fasciculation
GO:0021536 diencephalon development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048842 positive regulation of axon extension involved in axon guidance
GO:0048843 negative regulation of axon extension involved in axon guidance
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000112902
View Gene Order
ENSBTAG00000005021
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04360
Axon guidance pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19200
Other semaphorin interactions pathway
REACT_111045
Developmental Biology pathway
REACT_22161
Post-translational protein modification pathway
REACT_19271
Semaphorin interactions pathway
REACT_18266
Axon guidance pathway
REACT_200727
O-linked glycosylation pathway
REACT_17015
Metabolism of proteins pathway
REACT_200626
O-glycosylation of TSR domain-containing proteins pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.260374
RefSeq NM_009154 XM_006520043 XM_006520044
OMIM
CCDS CCDS37055
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca