Version 5.4
Homo sapiens Gene: CHL1
Summary
InnateDB Gene IDBG-13308.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHL1
Gene Name cell adhesion molecule with homology to L1CAM (close homolog of L1)
Synonyms CALL; L1CAM2
Species Homo sapiens
Ensembl Gene ENSG00000134121
Encoded Proteins
IDBP-13310
cell adhesion molecule with homology to L1CAM (close homolog of L1)
IDBP-235244
cell adhesion molecule with homology to L1CAM (close homolog of L1)
IDBP-360621
cell adhesion molecule with homology to L1CAM (close homolog of L1)
IDBP-360628
cell adhesion molecule with homology to L1CAM (close homolog of L1)
IDBP-360629
cell adhesion molecule with homology to L1CAM (close homolog of L1)
IDBP-360630
cell adhesion molecule with homology to L1CAM (close homolog of L1)
IDBP-360631
cell adhesion molecule with homology to L1CAM (close homolog of L1)
IDBP-360633
cell adhesion molecule with homology to L1CAM (close homolog of L1)
IDBP-807040
cell adhesion molecule L1-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways. The deletion of one copy of this gene may be responsible for mental defects in patients with 3p- syndrome. This protein may also play a role in the growth of certain cancers. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:196596-409417
Strand Forward strand
Band p26.3
Transcripts
ENST00000256509 ENSP00000256509
ENST00000397491 ENSP00000380628
ENST00000427688 ENSP00000403311
ENST00000421198 ENSP00000413628
ENST00000435603 ENSP00000397445
ENST00000449294 ENSP00000390440
ENST00000445697 ENSP00000395239
ENST00000453040 ENSP00000413109
ENST00000481167
ENST00000489224
ENST00000486881
ENST00000461289
ENST00000471332
ENST00000470880
ENST00000470005
ENST00000620033 ENSP00000483512
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005515 protein binding
Biological Process
GO:0001764 neuron migration
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007411 axon guidance
GO:0008344 adult locomotory behavior
GO:0031103 axon regeneration
GO:0031175 neuron projection development
GO:0035640 exploration behavior
GO:0043524 negative regulation of neuron apoptotic process
GO:0050890 cognition
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030425 dendrite
GO:0045177 apical part of cell
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030077
View Gene Order
ENSBTAG00000002471
Not yet available
Pathways
NETPATH
REACTOME
REACT_22292
CHL1 interactions pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.148909 Hs.607023 Hs.607881 Hs.731409
RefSeq NM_001253387 NM_001253388 NM_006614 XM_006712938 XM_006712939 XM_006712940 XM_006712941
HUGO
OMIM
CCDS CCDS2556 CCDS58812 CCDS74887
HPRD 07598
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca