InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mtdh

Summary

InnateDB Gene

IDBG-133453.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mtdh

Gene Name

metadherin

Synonyms

2610103J23Rik; 3D3; 3D3/Lyric; AEG-1; AV353288; D8Bwg1112e; Lyric

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022255

Encoded Proteins

IDBP-133455

metadherin

IDBP-624797

metadherin

IDBP-624799

metadherin

IDBP-624800

metadherin

IDBP-624802

metadherin

IDBP-624805

metadherin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147649:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:34082694-34142386

Strand

Forward strand

Band

B3.1

Transcripts

ENSMUST00000022865	ENSMUSP00000022865
ENSMUST00000172082
ENSMUST00000163697
ENSMUST00000168991	ENSMUSP00000129500
ENSMUST00000163333	ENSMUSP00000130190
ENSMUST00000170050	ENSMUSP00000128288
ENSMUST00000170553	ENSMUSP00000126167
ENSMUST00000172083
ENSMUST00000169905	ENSMUSP00000131814
ENSMUST00000171711

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001085	RNA polymerase II transcription factor binding
GO:0003713	transcription coactivator activity
GO:0003725	double-stranded RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0051059	NF-kappaB binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0010508	positive regulation of autophagy
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0043066	negative regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045766	positive regulation of angiogenesis
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051897	positive regulation of protein kinase B signaling
GO:0070830	tight junction assembly

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005923	tight junction
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0016604	nuclear body
GO:0031965	nuclear membrane
GO:0046581	intercellular canaliculus
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000147649

View Gene Order

ENSBTAG00000003098

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_24

TSLP pathway

REACTOME

KEGG

INOH

PID NCI

myc_activpathway

Validated targets of C-MYC transcriptional activation

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.130883 Mm.398968 Mm.416821 Mm.467208

RefSeq

NM_026002

OMIM

CCDS

CCDS27415

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas