Version 5.4
Mus musculus Gene: Ndp
Summary
InnateDB Gene IDBG-133690.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ndp
Gene Name Norrie disease (pseudoglioma) (human)
Synonyms ND; Ndph
Species Mus musculus
Ensembl Gene ENSMUSG00000040138
Encoded Proteins
IDBP-133692
Norrie disease (pseudoglioma) (human)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124479:
This gene encodes a secreted protein with a cystein-knot motif that activates the Wnt/beta-catenin pathway. The protein forms disulfide-linked oligomers in the extracellular matrix. Mutations in this gene result in Norrie disease and X-linked exudative vitreoretinopathy. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:16885521-16911774
Strand Reverse strand
Band A1.2
Transcripts
ENSMUST00000040134 ENSMUSP00000046692
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005109 frizzled binding
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001890 placenta development
GO:0016055 Wnt signaling pathway
GO:0035426 extracellular matrix-cell signaling
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060070 canonical Wnt signaling pathway
GO:0061299 retina vasculature morphogenesis in camera-type eye
Cellular Component
GO:0005615 extracellular space
GO:0009986 cell surface
GO:0031012 extracellular matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000124479
View Gene Order
ENSBTAG00000012623
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
INOH website
GPCR signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt P48744
TrEMBL
UniProt Splice Variant
Entrez Gene 17986
UniGene Mm.5014
RefSeq NM_010883
OMIM
CCDS CCDS30034
HPRD
IMGT
MGI ID MGI:102570
MGI Symbol Ndp
EMBL AL732321 BC090623 X83794 X92397
GenPept AAH90623 CAA58725 CAA63134 CAM16089
RNA Seq Atlas 17986

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca