Version 5.4
Mus musculus Gene: Plagl1
Summary
InnateDB Gene IDBG-134075.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Plagl1
Gene Name pleiomorphic adenoma gene-like 1
Synonyms Lot1; Zac1
Species Mus musculus
Ensembl Gene ENSMUSG00000019817
Encoded Proteins
IDBP-401692
pleiomorphic adenoma gene-like 1
IDBP-401691
pleiomorphic adenoma gene-like 1
IDBP-401690
pleiomorphic adenoma gene-like 1
IDBP-534484
pleiomorphic adenoma gene-like 1
IDBP-540580
pleiomorphic adenoma gene-like 1
IDBP-537279
pleiomorphic adenoma gene-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118495:
This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activities. It has been shown to have anti-proliferative properties, and thus thought to function as a tumor suppressor. In addition, overexpression of this gene during fetal development is believed to underlie the rare disorder, transient neonatal diabetes mellitus (TNDM). This gene is imprinted, with preferential expression of the paternal allele in many tissues, however, biallelic expression has been noted in peripheral blood leucocytes. A recent study reports that tissue-specific imprinting results from variable utilization of monoallelic and biallelic promoters. Many transcript variants differing in the 5' UTR and encoding two different isoforms, have been found for this gene. [provided by RefSeq, Oct 2010]
This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activities. It has been shown to have anti-proliferative properties, and thus thought to function as a tumor suppressor. In addition, overexpression of this gene during fetal development is believed to underlie the rare disorder, transient neonatal diabetes mellitus (TNDM). This gene is imprinted, with preferential expression of the paternal allele in many tissues, however, biallelic expression has been noted in peripheral blood leucocytes. A recent study reports that tissue-specific imprinting results from variable utilization of monoallelic and biallelic promoters. Many transcript variants differing in the 5\' UTR and encoding two different isoforms, have been found for this gene. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:13090691-13131694
Strand Forward strand
Band A2
Transcripts
ENSMUST00000121325 ENSMUSP00000112889
ENSMUST00000121766 ENSMUSP00000113710
ENSMUST00000121646 ENSMUSP00000112847
ENSMUST00000123135
ENSMUST00000135095
ENSMUST00000124252
ENSMUST00000130894
ENSMUST00000129989
ENSMUST00000144437
ENSMUST00000130449
ENSMUST00000139262
ENSMUST00000135826
ENSMUST00000138433
ENSMUST00000150773
ENSMUST00000149881
ENSMUST00000141068
ENSMUST00000126880
ENSMUST00000135261
ENSMUST00000130638
ENSMUST00000130800
ENSMUST00000141944
ENSMUST00000143582 ENSMUSP00000115595
ENSMUST00000130313 ENSMUSP00000117321
ENSMUST00000145103 ENSMUSP00000120581
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006366 transcription from RNA polymerase II promoter
GO:0006915 apoptotic process
GO:0010468 regulation of gene expression
GO:0035914 skeletal muscle cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000118495
View Gene Order
ENSBTAG00000026523
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.287857 Mm.415700 Mm.488054
RefSeq NM_009538
OMIM
CCDS CCDS48501
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca