InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ezr

Summary

InnateDB Gene

IDBG-134163.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ezr

Gene Name

ezrin

Synonyms

AW146364; p81; R75297; Vil2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000052397

Encoded Proteins

IDBP-134167

ezrin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000092820:
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:6738041-6782784

Strand

Reverse strand

Band

Transcripts

ENSMUST00000064234	ENSMUSP00000063734
ENSMUST00000131131

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 79 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	79 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0019904	protein domain specific binding
GO:0032403	protein complex binding
GO:0044822	poly(A) RNA binding
GO:0050839	cell adhesion molecule binding
GO:0051015	actin filament binding

Biological Process

GO:0007159	leukocyte cell-cell adhesion
GO:0008360	regulation of cell shape
GO:0010628	positive regulation of gene expression
GO:0022614	membrane to membrane docking
GO:0030855	epithelial cell differentiation
GO:0031623	receptor internalization
GO:0035088	establishment or maintenance of apical/basal cell polarity
GO:0046847	filopodium assembly
GO:0051017	actin filament bundle assembly
GO:0061028	establishment of endothelial barrier

Cellular Component

GO:0001726	ruffle
GO:0001931	uropod
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005884	actin filament
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0005925	focal adhesion
GO:0005938	cell cortex
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0019898	extrinsic component of membrane
GO:0030175	filopodium
GO:0030315	T-tubule
GO:0031528	microvillus membrane
GO:0032587	ruffle membrane
GO:0036064	ciliary basal body
GO:0044297	cell body
GO:0044393	microspike
GO:0045121	membrane raft
GO:0045177	apical part of cell
GO:0051286	cell tip
GO:0070062	extracellular vesicular exosome
GO:0097449	astrocyte projection
GO:0097454	Schwann cell microvillus