InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cnr1

Summary

InnateDB Gene

IDBG-134736.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cnr1

Gene Name

cannabinoid receptor 1 (brain)

Synonyms

CB-R; CB1; CB1R

Species

Mus musculus

Ensembl Gene

ENSMUSG00000044288

Encoded Proteins

IDBP-134738

cannabinoid receptor 1 (brain)

IDBP-134740

cannabinoid receptor 1 (brain)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118432:
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:33924593-33948831

Strand

Forward strand

Band

Transcripts

ENSMUST00000084736	ENSMUSP00000081787
ENSMUST00000057188	ENSMUSP00000055797
ENSMUST00000133462

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004949	cannabinoid receptor activity
GO:0005515	protein binding
GO:0008144	drug binding

Biological Process

GO:0002866	positive regulation of acute inflammatory response to antigenic stimulus
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007283	spermatogenesis
GO:0007568	aging
GO:0007584	response to nutrient
GO:0007611	learning or memory
GO:0007613	memory
GO:0010976	positive regulation of neuron projection development
GO:0019216	regulation of lipid metabolic process
GO:0019233	sensory perception of pain
GO:0031622	positive regulation of fever generation
GO:0031999	negative regulation of fatty acid beta-oxidation
GO:0032228	regulation of synaptic transmission, GABAergic
GO:0032496	response to lipopolysaccharide
GO:0033004	negative regulation of mast cell activation
GO:0033602	negative regulation of dopamine secretion
GO:0035094	response to nicotine
GO:0038171	cannabinoid signaling pathway
GO:0042220	response to cocaine
GO:0042593	glucose homeostasis
GO:0043065	positive regulation of apoptotic process
GO:0043271	negative regulation of ion transport
GO:0043278	response to morphine
GO:0045471	response to ethanol
GO:0045759	negative regulation of action potential
GO:0045776	negative regulation of blood pressure
GO:0045777	positive regulation of blood pressure
GO:0050796	regulation of insulin secretion
GO:0051001	negative regulation of nitric-oxide synthase activity
GO:0051966	regulation of synaptic transmission, glutamatergic
GO:0060135	maternal process involved in female pregnancy
GO:0060259	regulation of feeding behavior
GO:0060405	regulation of penile erection