Version 5.4
Mus musculus Gene: Spaca1
Summary
InnateDB Gene IDBG-134769.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spaca1
Gene Name sperm acrosome associated 1
Synonyms 1700124L11Rik; 4930540L03Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000028264
Encoded Proteins
IDBP-134771
sperm acrosome associated 1
IDBP-134773
sperm acrosome associated 1
IDBP-265144
sperm acrosome associated 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118434:
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from infertile males. Furthermore, antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to the acrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesis and in sperm-egg binding and fusion, respectively. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:34024874-34050191
Strand Reverse strand
Band A5
Transcripts
ENSMUST00000084734 ENSMUSP00000081785
ENSMUST00000029927 ENSMUSP00000029927
ENSMUST00000108148 ENSMUSP00000103783
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0001675 acrosome assembly
GO:0007283 spermatogenesis
Cellular Component
GO:0002080 acrosomal membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000118434
View Gene Order
ENSBTAG00000019469
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.55848
RefSeq NM_001290443 NM_026293 XM_006538207
OMIM
CCDS CCDS18026 CCDS71357
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca