InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tnik

Summary

InnateDB Gene

IDBG-134833.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnik

Gene Name

TRAF2 and NCK interacting kinase

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027692

Encoded Proteins

IDBP-537450

TRAF2 and NCK interacting kinase

IDBP-536287

TRAF2 and NCK interacting kinase

IDBP-537207

TRAF2 and NCK interacting kinase

IDBP-539942

TRAF2 and NCK interacting kinase

IDBP-539664

TRAF2 and NCK interacting kinase

IDBP-532585

TRAF2 and NCK interacting kinase

IDBP-535873

TRAF2 and NCK interacting kinase

IDBP-535834

TRAF2 and NCK interacting kinase

IDBP-538441

TRAF2 and NCK interacting kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154310:
Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:28263214-28675858

Strand

Forward strand

Band

Transcripts

ENSMUST00000160934	ENSMUSP00000123859
ENSMUST00000159236	ENSMUSP00000124681
ENSMUST00000161234
ENSMUST00000161214
ENSMUST00000160518	ENSMUSP00000124011
ENSMUST00000162485	ENSMUSP00000124387
ENSMUST00000159680	ENSMUSP00000124876
ENSMUST00000159308	ENSMUSP00000125466
ENSMUST00000162037
ENSMUST00000162777	ENSMUSP00000124726
ENSMUST00000161964	ENSMUSP00000125411
ENSMUST00000160307	ENSMUSP00000125081
ENSMUST00000161423
ENSMUST00000162225
ENSMUST00000159733

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 104 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	104 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005083	small GTPase regulator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007010	cytoskeleton organization
GO:0007256	activation of JNKK activity
GO:0016055	Wnt signaling pathway
GO:0023014	signal transduction by phosphorylation
GO:0031532	actin cytoskeleton reorganization
GO:0035556	intracellular signal transduction
GO:0046777	protein autophosphorylation
GO:0048814	regulation of dendrite morphogenesis
GO:0050790	regulation of catalytic activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0048471	perinuclear region of cytoplasm
GO:0055037	recycling endosome
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000154310

View Gene Order

ENSBTAG00000011742

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_120956

Cellular responses to stress pathway

REACT_169274

Cellular Senescence pathway

REACT_169436

Oxidative Stress Induced Senescence pathway

KEGG

INOH

PID NCI

betacatenin_nuc_pathway

Regulation of nuclear beta catenin signaling and target gene transcription

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.483052

RefSeq

NM_001163007 NM_001163008 NM_001163009 NM_026910 XM_006535517 XM_006535518 XM_006535519 XM_006535520

OMIM

CCDS

CCDS50877 CCDS50878 CCDS50879

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas