InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Aco1

Summary

InnateDB Gene

IDBG-135868.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aco1

Gene Name

aconitase 1

Synonyms

Aco-1; Irebp; Irp1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028405

Encoded Proteins

IDBP-135870

aconitase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 26190773

Macrophage iron regulatory proteins Aco1 and Ireb2 are protective against Salmonella by promoting the induction of Lcn2, a host antimicrobial factor that inhibits bacterial uptake of iron-laden siderophores, and by suppressing the ferritin iron pool.

Entrez Gene

Summary

This gene encodes a member of the aconitase/IPM isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Depending on iron levels in the cytosol, the encoded protein can function as either an aconitase enzyme or as an mRNA binding protein. When cellular iron levels are high, the encoded protein functions as an aconitase, an essential enzyme in the TCA cycle that catalyzes the conversion of citrate to isocitrate. When cellular iron levels are low, the encoded protein regulates iron uptake and utilization by binding to iron-responsive elements in the untranslated regions of mRNAs for genes involved in iron metabolism. Disruption of this gene is associated with pulmonary hypertension and polycythemia. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:40143081-40198338

Strand

Forward strand

Band

Transcripts

ENSMUST00000102973	ENSMUSP00000100038
ENSMUST00000152911
ENSMUST00000142360
ENSMUST00000135787

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003994	aconitate hydratase activity
GO:0005515	protein binding
GO:0030350	iron-responsive element binding
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0006099	tricarboxylic acid cycle
GO:0006101	citrate metabolic process
GO:0006417	regulation of translation
GO:0006879	cellular iron ion homeostasis
GO:0008152	metabolic process
GO:0009791	post-embryonic development
GO:0010040	response to iron(II) ion
GO:0010468	regulation of gene expression
GO:0045087	innate immune response (InnateDB)
GO:0050892	intestinal absorption

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000122729

View Gene Order

ENSBTAG00000000555

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu00020

Citrate cycle (TCA cycle) pathway

mmu00630

Glyoxylate and dicarboxylate metabolism pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa00020

Citrate cycle (TCA cycle) pathway

hsa00630

Glyoxylate and dicarboxylate metabolism pathway

INOH

INOH website

Citrate cycle pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.331547

RefSeq

NM_007386

OMIM

CCDS

CCDS18042

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas