Version 5.4
| Mus musculus Gene: Prkcq | |||||||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-136196.6 | ||||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||
| Gene Symbol | Prkcq | ||||||||||||||||||||||||||||||||||
| Gene Name | protein kinase C, theta | ||||||||||||||||||||||||||||||||||
| Synonyms | A130035A12Rik; AW494342; PKC-0; PKC-theta; Pkcq; PKCtheta | ||||||||||||||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000026778 | ||||||||||||||||||||||||||||||||||
| Encoded Proteins |
protein kinase C, theta
protein kinase C, theta
protein kinase C, theta
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| Protein Structure | |||||||||||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000065675:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 2:11172113-11301226 | ||||||||||||||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||||||||||||||
| Band | A1 | ||||||||||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||||||
| REACTOME |
Innate Immune System pathway
Apoptosis pathway
GPCR downstream signaling pathway
Disease pathway
Hemostasis pathway
Signaling by GPCR pathway
Downstream TCR signaling pathway
Netrin-1 signaling pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
FCERI mediated NF-kB activation pathway
Apoptotic cleavage of cellular proteins pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
Effects of PIP2 hydrolysis pathway
G alpha (z) signalling events pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
Adaptive Immune System pathway
Developmental Biology pathway
Visual phototransduction pathway
Inactivation, recovery and regulation of the phototransduction cascade pathway
The phototransduction cascade pathway
G alpha (q) signalling events pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
TCR signaling pathway
Apoptotic execution phase pathway
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| KEGG |
Tight junction pathway
T cell receptor signaling pathway pathway
Adipocytokine signaling pathway pathway
Vascular smooth muscle contraction pathway
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| INOH |
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
GPCR signaling pathway
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| PID NCI | |||||||||||||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||
| NETPATH |
Wnt pathway
TNFalpha pathway
TCR pathway
BCR pathway
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| REACTOME |
Downstream TCR signaling pathway
Effects of PIP2 hydrolysis pathway
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (z) signalling events pathway
Apoptotic cleavage of cellular proteins pathway
Apoptotic execution phase pathway
Netrin-1 signaling pathway
Developmental Biology pathway
FCERI mediated NF-kB activation pathway
TCR signaling pathway
Signaling by GPCR pathway
Innate Immune System pathway
Platelet activation, signaling and aggregation pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
Apoptosis pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Adaptive Immune System pathway
Diseases associated with visual transduction pathway
Immune System pathway
Visual phototransduction pathway
The phototransduction cascade pathway
Inactivation, recovery and regulation of the phototransduction cascade pathway
Disease pathway
Hemostasis pathway
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| KEGG |
Tight junction pathway
T cell receptor signaling pathway pathway
Adipocytokine signaling pathway pathway
Vascular smooth muscle contraction pathway
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| INOH |
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
GPCR signaling pathway
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| PID NCI |
TCR signaling in naïve CD8+ T cells
TCR signaling in naïve CD4+ T cells
Downstream signaling in naïve CD8+ T cells
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
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| Cross-References | |||||||||||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||||||
| UniGene | Mm.329993 | ||||||||||||||||||||||||||||||||||
| RefSeq | NM_008859 XM_006497398 | ||||||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||||||
| CCDS | CCDS15682 | ||||||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||||
| MGI ID | |||||||||||||||||||||||||||||||||||
| MGI Symbol | |||||||||||||||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||||||||||||||