Version 5.4
| Mus musculus Gene: Pik3ca | |||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-136530.6 | ||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||
| Gene Symbol | Pik3ca | ||||||||||||||||||||||||||||||
| Gene Name | phosphatidylinositol 3-kinase, catalytic, alpha polypeptide | ||||||||||||||||||||||||||||||
| Synonyms | 6330412C24Rik; caPI3K; p110; p110alpha | ||||||||||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000027665 | ||||||||||||||||||||||||||||||
| Encoded Proteins |
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||
| Summary |
[Homo sapiens] PIK3CA, as the alpha subunit of PI3K, functions as a negative regulator of TLR signalling. The activation of PIK3CA results in the inhibition of pro-inflammatory events such as expression of IL12 and TNFA.
[Homo sapiens] PIK3CA and PIK3CB isoforms of class IA phosphatidylinositol 3-kinase (PI3K) are both required for the pro-inflammatory response to flagellin.
[Homo sapiens] MIR203A accelerates apoptosis in LPS-stimulated alveolar epithelial cells by targeting PIK3CA.
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| Entrez Gene | |||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121879:
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 3:32397671-32468486 | ||||||||||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||||||||||
| Band | A3 | ||||||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 57 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||
| REACTOME |
Innate Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
GPCR downstream signaling pathway
PI3K/AKT activation pathway
Synthesis of PIPs at the plasma membrane pathway
CD28 dependent PI3K/Akt signaling pathway
Disease pathway
Hemostasis pathway
Nephrin interactions pathway
Signaling by constitutively active EGFR pathway
Signaling by GPCR pathway
Signaling by Insulin receptor pathway
Interleukin-2 signaling pathway
Role of phospholipids in phagocytosis pathway
Downstream TCR signaling pathway
Signaling by VEGF pathway
Signaling by FGFR in disease pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
PI Metabolism pathway
Cytokine Signaling in Immune system pathway
PIP3 activates AKT signaling pathway
Cell surface interactions at the vascular wall pathway
Metabolism pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
Metabolism of lipids and lipoproteins pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
PI3K events in ERBB4 signaling pathway
PI-3K cascade pathway
Signaling by EGFR pathway
GPVI-mediated activation cascade pathway
Insulin receptor signalling cascade pathway
G alpha (12/13) signalling events pathway
IRS-related events triggered by IGF1R pathway
IGF1R signaling cascade pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
CD28 co-stimulation pathway
Interleukin receptor SHC signaling pathway
Costimulation by the CD28 family pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
PI3K Cascade pathway
VEGFA-VEGFR2 Pathway pathway
Fc epsilon receptor (FCERI) signaling pathway
Signaling by Interleukins pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR mutants pathway
Signaling by FGFR1 mutants pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
GAB1 signalosome pathway
Signaling by FGFR1 fusion mutants pathway
Phospholipid metabolism pathway
IRS-related events pathway
NGF signalling via TRKA from the plasma membrane pathway
G alpha (q) signalling events pathway
IRS-mediated signalling pathway
G-protein beta:gamma signalling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
PI3K events in ERBB2 signaling pathway
Signal Transduction pathway
Tie2 Signaling pathway
G beta:gamma signalling through PI3Kgamma pathway
Signaling by FGFR pathway
Cell-Cell communication pathway
TCR signaling pathway
Signaling by EGFR in Cancer pathway
Regulation of signaling by CBL pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
DAP12 interactions pathway
DAP12 signaling pathway
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| KEGG |
Endometrial cancer pathway
Renal cell carcinoma pathway
ErbB signaling pathway pathway
Type II diabetes mellitus pathway
VEGF signaling pathway pathway
Jak-STAT signaling pathway pathway
Insulin signaling pathway pathway
Acute myeloid leukemia pathway
T cell receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
Colorectal cancer pathway
Fc epsilon RI signaling pathway pathway
Melanoma pathway
Natural killer cell mediated cytotoxicity pathway
Phosphatidylinositol signaling system pathway
Regulation of actin cytoskeleton pathway
Glioma pathway
mTOR signaling pathway pathway
Small cell lung cancer pathway
Leukocyte transendothelial migration pathway
Apoptosis pathway
Prostate cancer pathway
Chronic myeloid leukemia pathway
Inositol phosphate metabolism pathway
Non-small cell lung cancer pathway
Focal adhesion pathway
B cell receptor signaling pathway pathway
Pancreatic cancer pathway
Fc gamma R-mediated phagocytosis pathway
Chemokine signaling pathway pathway
Neurotrophin signaling pathway pathway
Pathways in cancer pathway
Progesterone-mediated oocyte maturation pathway
Aldosterone-regulated sodium reabsorption pathway
Amoebiasis pathway
Osteoclast differentiation pathway
Carbohydrate digestion and absorption pathway
Toxoplasmosis pathway
Hepatitis C pathway
Chagas disease (American trypanosomiasis) pathway
Bacterial invasion of epithelial cells pathway
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| INOH |
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
B cell receptor signaling pathway
EPO signaling pathway pathway
FGF signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
HGF signaling pathway pathway
PDGF signaling pathway pathway
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| PID NCI | |||||||||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||
| NETPATH |
Alpha6Beta4Integrin pathway
EGFR1 pathway
KitReceptor pathway
TGF_beta_Receptor pathway
IL2 pathway
IL4 pathway
TSH pathway
TSLP pathway
Prolactin pathway
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| REACTOME |
PIP3 activates AKT signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
Role of phospholipids in phagocytosis pathway
Downstream TCR signaling pathway
Regulation of signaling by CBL pathway
Interleukin receptor SHC signaling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Interleukin-2 signaling pathway
CD28 dependent PI3K/Akt signaling pathway
CD28 co-stimulation pathway
Costimulation by the CD28 family pathway
Tie2 Signaling pathway
Cell surface interactions at the vascular wall pathway
GPVI-mediated activation cascade pathway
PI3K/AKT activation pathway
GAB1 signalosome pathway
Signaling by EGFR pathway
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G beta:gamma signalling through PI3Kgamma pathway
G alpha (12/13) signalling events pathway
PI3K events in ERBB4 signaling pathway
Signaling by ERBB4 pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
IRS-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
PI3K events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
PI-3K cascade pathway
Signaling by FGFR pathway
Signaling by SCF-KIT pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Synthesis of PIPs at the plasma membrane pathway
Signaling by constitutively active EGFR pathway
Signaling by FGFR1 fusion mutants pathway
Signaling by FGFR mutants pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Nephrin interactions pathway
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Metabolism of lipids and lipoproteins pathway
Cell-Cell communication pathway
TCR signaling pathway
Signaling by VEGF pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Innate Immune System pathway
Signaling by FGFR1 mutants pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
IRS-mediated signalling pathway
Adaptive Immune System pathway
Immune System pathway
Insulin receptor signalling cascade pathway
Signaling by Interleukins pathway
VEGFA-VEGFR2 Pathway pathway
NGF signalling via TRKA from the plasma membrane pathway
PI Metabolism pathway
Phospholipid metabolism pathway
IRS-related events pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
IGF1R signaling cascade pathway
PI3K/AKT Signaling in Cancer pathway
Metabolism pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
Hemostasis pathway
DAP12 interactions pathway
Insulin receptor signalling cascade pathway
CD28 dependent PI3K/Akt signaling pathway
Signaling by FGFR1 mutants pathway
Signaling by EGFR pathway
Cell surface interactions at the vascular wall pathway
GAB1 signalosome pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
IRS-related events triggered by IGF1R pathway
Regulation of signaling by CBL pathway
Synthesis of PIPs at the plasma membrane pathway
Signaling by GPCR pathway
Signaling by PDGF pathway
Tie2 Signaling pathway
Signaling by ERBB4 pathway
Costimulation by the CD28 family pathway
Signaling by FGFR pathway
Signaling by FGFR mutants pathway
Interleukin-2 signaling pathway
Cytokine Signaling in Immune system pathway
Downstream TCR signaling pathway
IRS-related events pathway
VEGFA-VEGFR2 Pathway pathway
Nephrin interactions pathway
Hemostasis pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
PI3K events in ERBB2 signaling pathway
Immune System pathway
IRS-mediated signalling pathway
Interleukin receptor SHC signaling pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Platelet activation, signaling and aggregation pathway
IGF1R signaling cascade pathway
CD28 co-stimulation pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
Signal Transduction pathway
GPVI-mediated activation cascade pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
Cell-Cell communication pathway
Signaling by EGFR in Cancer pathway
Role of phospholipids in phagocytosis pathway
PI-3K cascade pathway
Metabolism of lipids and lipoproteins pathway
NGF signalling via TRKA from the plasma membrane pathway
G alpha (q) signalling events pathway
PI3K events in ERBB4 signaling pathway
GPCR downstream signaling pathway
Downstream signaling of activated FGFR pathway
Signaling by constitutively active EGFR pathway
Metabolism pathway
Signalling by NGF pathway
Signaling by VEGF pathway
G alpha (12/13) signalling events pathway
Signaling by FGFR1 fusion mutants pathway
PI3K/AKT Signaling in Cancer pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Adaptive Immune System pathway
Phospholipid metabolism pathway
G-protein beta:gamma signalling pathway
Downstream signal transduction pathway
PIP3 activates AKT signaling pathway
PI Metabolism pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Signaling by SCF-KIT pathway
Innate Immune System pathway
PI3K/AKT activation pathway
Signaling by Interleukins pathway
DAP12 signaling pathway
Disease pathway
Signaling by FGFR in disease pathway
G beta:gamma signalling through PI3Kgamma pathway
Fc epsilon receptor (FCERI) signaling pathway
TCR signaling pathway
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| KEGG |
Regulation of actin cytoskeleton pathway
mTOR signaling pathway pathway
Acute myeloid leukemia pathway
VEGF signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Colorectal cancer pathway
Non-small cell lung cancer pathway
Inositol phosphate metabolism pathway
ErbB signaling pathway pathway
Renal cell carcinoma pathway
Apoptosis pathway
Melanoma pathway
Endometrial cancer pathway
Leukocyte transendothelial migration pathway
Glioma pathway
Small cell lung cancer pathway
Phosphatidylinositol signaling system pathway
Insulin signaling pathway pathway
B cell receptor signaling pathway pathway
Prostate cancer pathway
Focal adhesion pathway
T cell receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
Type II diabetes mellitus pathway
Natural killer cell mediated cytotoxicity pathway
Chronic myeloid leukemia pathway
Pancreatic cancer pathway
Fc gamma R-mediated phagocytosis pathway
Neurotrophin signaling pathway pathway
Chemokine signaling pathway pathway
Pathways in cancer pathway
Progesterone-mediated oocyte maturation pathway
Aldosterone-regulated sodium reabsorption pathway
Amoebiasis pathway
Bacterial invasion of epithelial cells pathway
Chagas disease (American trypanosomiasis) pathway
Osteoclast differentiation pathway
Toxoplasmosis pathway
Carbohydrate digestion and absorption pathway
Hepatitis C pathway
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| INOH |
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
B cell receptor signaling pathway
EPO signaling pathway pathway
FGF signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
HGF signaling pathway pathway
IGF1 signaling pathway pathway
Inositol phosphate metabolism pathway
PDGF signaling pathway pathway
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| PID NCI |
Trk receptor signaling mediated by PI3K and PLC-gamma
Nongenotropic Androgen signaling
Atypical NF-kappaB pathway
E-cadherin signaling in the nascent adherens junction
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
IL2-mediated signaling events
Reelin signaling pathway
Netrin-mediated signaling events
Integrins in angiogenesis
IL1-mediated signaling events
VEGFR3 signaling in lymphatic endothelium
Signaling events mediated by PTP1B
PAR1-mediated thrombin signaling events
Nectin adhesion pathway
a6b1 and a6b4 Integrin signaling
Signaling events mediated by focal adhesion kinase
IGF1 pathway
EPHB forward signaling
Neurotrophic factor-mediated Trk receptor signaling
p75(NTR)-mediated signaling
FGF signaling pathway
BCR signaling pathway
Angiopoietin receptor Tie2-mediated signaling
Signaling events mediated by Stem cell factor receptor (c-Kit)
Ephrin B reverse signaling
IL23-mediated signaling events
IL4-mediated signaling events
CDC42 signaling events
Signaling events mediated by VEGFR1 and VEGFR2
IL3-mediated signaling events
Plasma membrane estrogen receptor signaling
Signaling events regulated by Ret tyrosine kinase
Signaling events mediated by the Hedgehog family
SHP2 signaling
IL2 signaling events mediated by STAT5
GMCSF-mediated signaling events
EPHA2 forward signaling
Fc-epsilon receptor I signaling in mast cells
VEGFR1 specific signals
E-cadherin signaling in keratinocytes
PDGFR-alpha signaling pathway
IL2 signaling events mediated by PI3K
IL6-mediated signaling events
Insulin Pathway
N-cadherin signaling events
IFN-gamma pathway
IL5-mediated signaling events
Osteopontin-mediated events
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| Cross-References | |||||||||||||||||||||||||||||||
| SwissProt | P42337 | ||||||||||||||||||||||||||||||
| TrEMBL | D3YY41 | ||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||
| Entrez Gene | 18706 | ||||||||||||||||||||||||||||||
| UniGene | Mm.260521 Mm.462541 Mm.474860 | ||||||||||||||||||||||||||||||
| RefSeq | NM_008839 XM_006535409 XM_006535410 | ||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||
| CCDS | CCDS38409 | ||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||
| MGI ID | MGI:1206581 | ||||||||||||||||||||||||||||||
| MGI Symbol | Pik3ca | ||||||||||||||||||||||||||||||
| EMBL | AC110034 AC130281 BC089038 BC130228 CH466530 U03279 | ||||||||||||||||||||||||||||||
| GenPept | AAA18334 AAH89038 AAI30229 EDL34989 EDL34990 | ||||||||||||||||||||||||||||||
| RNA Seq Atlas | 18706 | ||||||||||||||||||||||||||||||