Version 5.4
Mus musculus Gene: Ctnna1
Summary
InnateDB Gene IDBG-136630.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ctnna1
Gene Name catenin (cadherin associated protein), alpha 1
Synonyms 2010010M04Rik; AA517462; AI988031; Catna1
Species Mus musculus
Ensembl Gene ENSMUSG00000037815
Encoded Proteins
IDBP-136632
catenin (cadherin associated protein), alpha 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000044115:
Gene Information
Type Protein coding
Genomic Location Chromosome 18:35118888-35254773
Strand Forward strand
Band B1
Transcripts
ENSMUST00000042345 ENSMUSP00000049007
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 47 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0017166 vinculin binding
GO:0044822 poly(A) RNA binding
GO:0045295 gamma-catenin binding
GO:0045296 cadherin binding
GO:0051015 actin filament binding
Biological Process
GO:0001541 ovarian follicle development
GO:0007155 cell adhesion
GO:0007163 establishment or maintenance of cell polarity
GO:0007406 negative regulation of neuroblast proliferation
GO:0007568 aging
GO:0008584 male gonad development
GO:0014070 response to organic cyclic compound
GO:0016264 gap junction assembly
GO:0031103 axon regeneration
GO:0034613 cellular protein localization
GO:0042127 regulation of cell proliferation
GO:0042475 odontogenesis of dentin-containing tooth
GO:0043066 negative regulation of apoptotic process
GO:0043297 apical junction assembly
GO:0043627 response to estrogen
GO:0045880 positive regulation of smoothened signaling pathway
GO:0051291 protein heterooligomerization
GO:0071681 cellular response to indole-3-methanol
GO:0090136 epithelial cell-cell adhesion
GO:2000146 negative regulation of cell motility
GO:2001045 negative regulation of integrin-mediated signaling pathway
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0005913 cell-cell adherens junction
GO:0005915 zonula adherens
GO:0014704 intercalated disc
GO:0015629 actin cytoskeleton
GO:0016342 catenin complex
GO:0030027 lamellipodium
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000044115
View Gene Order
ENSBTAG00000014182
Not yet available
Pathways
NETPATH
REACTOME
REACT_227951
Signaling by VEGF pathway
REACT_248094
Cell-cell junction organization pathway
REACT_253473
Myogenesis pathway
REACT_258600
CDO in myogenesis pathway
REACT_230395
Adherens junctions interactions pathway
REACT_261840
VEGFR2 mediated vascular permeability pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_188576
Developmental Biology pathway
REACT_188257
Signal Transduction pathway
REACT_241978
Cell junction organization pathway
REACT_223082
Cell-Cell communication pathway
KEGG
mmu04530
Tight junction pathway
mmu05213
Endometrial cancer pathway
mmu04520
Adherens junction pathway
mmu04670
Leukocyte transendothelial migration pathway
mmu05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
mmu05200
Pathways in cancer pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_19195
Adherens junctions interactions pathway
REACT_21402
CDO in myogenesis pathway
REACT_111045
Developmental Biology pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_12529
Signaling by VEGF pathway
REACT_228016
VEGFR2 mediated vascular permeability pathway
REACT_111102
Signal Transduction pathway
REACT_21303
Myogenesis pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_19331
Cell-cell junction organization pathway
KEGG
hsa04520
Adherens junction pathway
hsa05213
Endometrial cancer pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04530
Tight junction pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05200
Pathways in cancer pathway
hsa05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
ecadherin_nascentaj_pathway
E-cadherin signaling in the nascent adherens junction
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
nectin_pathway
Nectin adhesion pathway
rac1_pathway
RAC1 signaling pathway
cdc42_pathway
CDC42 signaling events
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
ecadherin_stabilization_pathway
Stabilization and expansion of the E-cadherin adherens junction
ecadherin_keratinocyte_pathway
E-cadherin signaling in keratinocytes
arf6_traffickingpathway
Arf6 trafficking events
ncadherinpathway
N-cadherin signaling events
ajdiss_2pathway
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt P26231
TrEMBL Q545R0
UniProt Splice Variant
Entrez Gene 12385
UniGene Mm.18962 Mm.407439
RefSeq NM_009818 XM_006525548
OMIM
CCDS CCDS29139
HPRD
IMGT
MGI ID MGI:88274
MGI Symbol Ctnna1
EMBL AK004623 AK148496 AK159339 BC048163 BC105576 CH466557 D90362 X59990
GenPept AAH48163 AAI05577 BAA14376 BAB23418 BAE28588 BAE35001 CAA42607 EDK97123
RNA Seq Atlas 12385

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca