Version 5.4
Mus musculus Gene: Magi2
Summary
InnateDB Gene IDBG-136973.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Magi2
Gene Name membrane associated guanylate kinase, WW and PDZ domain containing 2
Synonyms Acvri1; Acvrinp1; Acvrip1; AIP-1; Magi-2; mKIAA0705; S-SCAM
Species Mus musculus
Ensembl Gene ENSMUSG00000040003
Encoded Proteins
IDBP-136975
membrane associated guanylate kinase, WW and PDZ domain containing 2
IDBP-136977
membrane associated guanylate kinase, WW and PDZ domain containing 2
IDBP-250016
membrane associated guanylate kinase, WW and PDZ domain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187391:
The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:19227046-20704798
Strand Forward strand
Band A3
Transcripts
ENSMUST00000088516 ENSMUSP00000085872
ENSMUST00000101558 ENSMUSP00000099094
ENSMUST00000115267 ENSMUSP00000110922
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0019902 phosphatase binding
GO:0030159 receptor signaling complex scaffold activity
GO:0030165 PDZ domain binding
GO:0031697 beta-1 adrenergic receptor binding
GO:0046332 SMAD binding
GO:0070699 type II activin receptor binding
Biological Process
GO:0002092 positive regulation of receptor internalization
GO:0007165 signal transduction
GO:0008285 negative regulation of cell proliferation
GO:0010976 positive regulation of neuron projection development
GO:0016482 cytoplasmic transport
GO:0030336 negative regulation of cell migration
GO:0032516 positive regulation of phosphoprotein phosphatase activity
GO:0032926 negative regulation of activin receptor signaling pathway
GO:0038180 nerve growth factor signaling pathway
GO:0043113 receptor clustering
GO:0051291 protein heterooligomerization
GO:0051898 negative regulation of protein kinase B signaling
GO:0060395 SMAD protein signal transduction
GO:0071850 mitotic cell cycle arrest
GO:0072015 glomerular visceral epithelial cell development
GO:1990090 cellular response to nerve growth factor stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0014069 postsynaptic density
GO:0030425 dendrite
GO:0036057 slit diaphragm
GO:0043234 protein complex
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000187391
View Gene Order
Pathways
NETPATH
REACTOME
REACT_257032
Nephrin interactions pathway
REACT_223082
Cell-Cell communication pathway
KEGG
mmu04530
Tight junction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_23832
Nephrin interactions pathway
REACT_111155
Cell-Cell communication pathway
KEGG
hsa04530
Tight junction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.332231 Mm.401875 Mm.427647
RefSeq NM_001170745 NM_001170746 NM_015823 XM_006535751
OMIM
CCDS CCDS39019 CCDS51424 CCDS51425
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca