Version 5.4
Mus musculus Gene: Hbs1l
Summary
InnateDB Gene IDBG-137031.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hbs1l
Gene Name Hbs1-like (S. cerevisiae)
Synonyms 2810035F15Rik; AI326327; eRFS
Species Mus musculus
Ensembl Gene ENSMUSG00000019977
Encoded Proteins
IDBP-137033
Hbs1-like (S. cerevisiae)
IDBP-137035
Hbs1-like (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112339:
This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:21295979-21368889
Strand Forward strand
Band A3
Transcripts
ENSMUST00000092674 ENSMUSP00000090344
ENSMUST00000020153 ENSMUSP00000020153
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006414 translational elongation
GO:0008150 biological_process
Cellular Component
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000112339
View Gene Order
ENSBTAG00000020174
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu03015
mRNA surveillance pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa03015
mRNA surveillance pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q69ZS7
TrEMBL L7N209 Q3TGM7
UniProt Splice Variant
Entrez Gene 56422
UniGene Mm.25527
RefSeq NM_001042593 NM_001145209 NM_019702
OMIM
CCDS CCDS35862 CCDS48513
HPRD
IMGT
MGI ID MGI:1891704
MGI Symbol Hbs1l
EMBL AC153557 AF087672 AK006626 AK012856 AK166140 AK168671 AK169281 AK173091 BC010251
GenPept AAD23351 AAH10251 BAB24679 BAB28515 BAD32369 BAE38593 BAE40521 BAE41039
RNA Seq Atlas 56422

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca