Version 5.4
Homo sapiens Gene: PLEKHG6
Summary
InnateDB Gene IDBG-13725.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLEKHG6
Gene Name pleckstrin homology domain containing, family G (with RhoGef domain) member 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000008323
Encoded Proteins
IDBP-13727
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
IDBP-13729
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
IDBP-236312
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
IDBP-362803
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
IDBP-596625
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 12:6310436-6328506
Strand Forward strand
Band p13.31
Transcripts
ENST00000011684 ENSP00000011684
ENST00000304581 ENSP00000304640
ENST00000396988 ENSP00000380185
ENST00000449001 ENSP00000393194
ENST00000536531 ENSP00000442836
ENST00000538208
ENST00000543000
ENST00000535616
ENST00000544743
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
Cellular Component
GO:0000922 spindle pole
GO:0005737 cytoplasm
GO:0032154 cleavage furrow
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038167
View Gene Order
ENSBTAG00000004208
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
rhoa_reg_pathway
Regulation of RhoA activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.631660
RefSeq NM_001144856 NM_001144857 NM_018173 XM_005253704
HUGO
OMIM
CCDS CCDS44808 CCDS8541
HPRD 07692
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca