Version 5.4
Mus musculus Gene: Mas1
Summary
InnateDB Gene IDBG-137347.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mas1
Gene Name MAS1 oncogene
Synonyms Mas-1; Mgra
Species Mus musculus
Ensembl Gene ENSMUSG00000068037
Encoded Proteins
IDBP-137349
MAS1 oncogene
IDBP-535245
MAS1 oncogene
IDBP-537226
MAS1 oncogene
IDBP-542442
MAS1 oncogene
IDBP-531895
MAS1 oncogene
IDBP-536576
MAS1 oncogene
IDBP-532480
MAS1 oncogene
IDBP-620740
MAS1 oncogene
IDBP-620741
MAS1 oncogene
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130368:
This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:12841079-12868143
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000089015 ENSMUSP00000086409
ENSMUST00000162333 ENSMUSP00000125108
ENSMUST00000161747 ENSMUSP00000123902
ENSMUST00000162119 ENSMUSP00000124952
ENSMUST00000162389 ENSMUSP00000124879
ENSMUST00000159223 ENSMUSP00000124295
ENSMUST00000159865 ENSMUSP00000124901
ENSMUST00000167152 ENSMUSP00000131341
ENSMUST00000165020 ENSMUSP00000132300
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001595 angiotensin receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0017046 peptide hormone binding
GO:0042277 peptide binding
Biological Process
GO:0001933 negative regulation of protein phosphorylation
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0007283 spermatogenesis
GO:0008284 positive regulation of cell proliferation
GO:0008584 male gonad development
GO:0014823 response to activity
GO:0021766 hippocampus development
GO:0034698 response to gonadotropin
GO:0038166 angiotensin-activated signaling pathway
GO:0042493 response to drug
GO:0043434 response to peptide hormone
GO:0045740 positive regulation of DNA replication
GO:0050727 regulation of inflammatory response
GO:0060732 positive regulation of inositol phosphate biosynthetic process
GO:0070528 protein kinase C signaling
GO:0071375 cellular response to peptide hormone stimulus
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000130368
View Gene Order
ENSBTAG00000031724
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04614
Renin-angiotensin system pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04614
Renin-angiotensin system pathway
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.425994
RefSeq NM_008552
OMIM
CCDS CCDS28394
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca