InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tcp1

Summary

InnateDB Gene

IDBG-137484.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tcp1

Gene Name

t-complex protein 1

Synonyms

AI528772; c-cpn; CCT; Cct1; Ccta; p63; Tcp-1; Tp63; TRic

Species

Mus musculus

Ensembl Gene

ENSMUSG00000068039

Encoded Proteins

IDBP-137486

t-complex protein 1

IDBP-541564

t-complex protein 1

IDBP-539018

t-complex protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120438:
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:12915701-12925067

Strand

Forward strand

Band

Transcripts

ENSMUST00000089024	ENSMUSP00000086418
ENSMUST00000147724
ENSMUST00000151287	ENSMUSP00000116108
ENSMUST00000143961	ENSMUSP00000116511
ENSMUST00000129632
ENSMUST00000133003
ENSMUST00000151715
ENSMUST00000134665
ENSMUST00000138709
ENSMUST00000137289

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 94 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	23 [view]
Protein-DNA	2 [view]
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	94 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0044822	poly(A) RNA binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0007339	binding of sperm to zona pellucida
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0000242	pericentriolar material
GO:0000792	heterochromatin
GO:0001669	acrosomal vesicle
GO:0002199	zona pellucida receptor complex
GO:0005720	nuclear heterochromatin
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005815	microtubule organizing center
GO:0005832	chaperonin-containing T-complex
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0030054	cell junction
GO:0044297	cell body
GO:0070062	extracellular vesicular exosome