Version 5.4
Mus musculus Gene: Defb14
Summary
InnateDB Gene IDBG-137815.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Defb14
Gene Name defensin beta 14
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000046354
Encoded Proteins
IDBP-137817
defensin beta 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20483750
Defb14 is a beta-defensin with direct antimicrobial properties that contribute to local innate immune responses and it aids in combating microbial invasion by being chemotactic for a broad spectrum of leukocytes in a CCR6- and CCR2-dependent manner.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 8:19194357-19195212
Strand Forward strand
Band A1.3
Transcripts
ENSMUST00000052601 ENSMUSP00000062781
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0042056 chemoattractant activity
Biological Process
GO:0006952 defense response
GO:0042742 defense response to bacterium
GO:0045087 innate immune response (InnateDB)
GO:0050918 positive chemotaxis
GO:0060326 cell chemotaxis
Cellular Component
GO:0005576 extracellular region
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_199049
Defensins pathway
REACT_199048
Beta defensins pathway
REACT_239142
Innate Immune System pathway
REACT_230745
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q7TNV9
TrEMBL
UniProt Splice Variant
Entrez Gene 244332
UniGene Mm.358923
RefSeq NM_183026 XM_006508792 XM_006508793 XM_006508794 XM_006508795 XM_006508796 XM_006508797
OMIM
CCDS CCDS40253
HPRD
IMGT
MGI ID MGI:2675345
MGI Symbol Defb14
EMBL AJ578468 BC116199
GenPept AAI16200 CAE17665
RNA Seq Atlas 244332

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca