Mus musculus Gene: Rdh8 | |||||||||||
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Summary | |||||||||||
InnateDB Gene | IDBG-137818.6 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | Rdh8 | ||||||||||
Gene Name | retinol dehydrogenase 8 | ||||||||||
Synonyms | |||||||||||
Species | Mus musculus | ||||||||||
Ensembl Gene | ENSMUSG00000053773 | ||||||||||
Encoded Proteins |
retinol dehydrogenase 8
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Protein Structure | |||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
Entrez Gene | |||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000080511:
All-trans-retinol dehydrogenase (RDH8) is a visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol in the presence of NADPH (Rattner et al., 2000 [PubMed 10753906]). It is a member of the short chain dehydrogenase/reductase family and is located in the outer segments of photoreceptors; hence it is also known as photoreceptor retinol dehydrogenase. It is important in the visual cycle by beginning the rhodopsin regeneration pathway by reducing all-trans-retinal, the product of bleached and hydrolysed rhodopsin (Rando, 2001 [PubMed 11710234]). This is a rate-limiting step in the visual cycle (Saari et al., 1998 [PubMed 9667000]).[supplied by OMIM, Mar 2008] |
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Gene Information | |||||||||||
Type | Protein coding | ||||||||||
Genomic Location | Chromosome 9:20818504-20826163 | ||||||||||
Strand | Forward strand | ||||||||||
Band | A3 | ||||||||||
Transcripts |
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Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||
NETPATH | |||||||||||
REACTOME | |||||||||||
KEGG |
Retinol metabolism pathway
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INOH | |||||||||||
PID NCI | |||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||
NETPATH | |||||||||||
REACTOME |
The canonical retinoid cycle in rods (twilight vision) pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
Visual phototransduction pathway
Disease pathway
The canonical retinoid cycle in rods (twilight vision) pathway
Visual phototransduction pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
Disease pathway
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KEGG |
Retinol metabolism pathway
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INOH | |||||||||||
PID NCI | |||||||||||
Cross-References | |||||||||||
SwissProt | |||||||||||
TrEMBL | D3Z6W3 | ||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 235033 | ||||||||||
UniGene | Mm.297661 | ||||||||||
RefSeq | NM_001030290 | ||||||||||
OMIM | |||||||||||
CCDS | CCDS22884 | ||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
MGI ID | MGI:2685028 | ||||||||||
MGI Symbol | Rdh8 | ||||||||||
EMBL | AC166365 | ||||||||||
GenPept | |||||||||||
RNA Seq Atlas | 235033 | ||||||||||