Version 5.4
Mus musculus Gene: Defb4
Summary
InnateDB Gene IDBG-137844.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Defb4
Gene Name defensin beta 4
Synonyms 2310001F05Rik; BD-4
Species Mus musculus
Ensembl Gene ENSMUSG00000059230
Encoded Proteins
IDBP-137846
defensin beta 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20483750
Defb4 is a beta-defensin with direct antimicrobial properties that contribute to local innate immune responses and it aids in combating microbial invasion by being chemotactic for a broad spectrum of leukocytes in a CCR6- and CCR2-dependent manner.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 8:19198706-19201545
Strand Forward strand
Band A1.3
Transcripts
ENSMUST00000081017 ENSMUSP00000079808
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006952 defense response
GO:0042742 defense response to bacterium
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
Orthologs
No orthologs found for this gene
Cross-References
SwissProt P82019
TrEMBL Q499H9
UniProt Splice Variant
Entrez Gene 56519
UniGene Mm.45276
RefSeq NM_019728
OMIM
CCDS CCDS40254
HPRD
IMGT
MGI ID MGI:1927667
MGI Symbol Defb4
EMBL AF155882 AF287475 AF288371 AK009061 AK009306 BC099882 BC099883 BC100674 BC100675 CH466566
GenPept AAD38852 AAG02197 AAG10514 AAH99882 AAH99883 AAI00675 AAI00676 BAB26051 BAB26207 EDL22232
RNA Seq Atlas 56519

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca