Version 5.4
Mus musculus Gene: Eif3e
Summary
InnateDB Gene IDBG-137965.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eif3e
Gene Name eukaryotic translation initiation factor 3, subunit E
Synonyms 48kDa; eIF3-p46; eIF3-p48; Eif3s6; Int6
Species Mus musculus
Ensembl Gene ENSMUSG00000022336
Encoded Proteins
IDBP-137967
eukaryotic translation initiation factor 3, subunit E
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104408:
Gene Information
Type Protein coding
Genomic Location Chromosome 15:43250040-43282736
Strand Reverse strand
Band B3.2
Transcripts
ENSMUST00000022960 ENSMUSP00000022960
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 89 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 89 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0001731 formation of translation preinitiation complex
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005852 eukaryotic translation initiation factor 3 complex
GO:0016020 membrane
GO:0016282 eukaryotic 43S preinitiation complex
GO:0016605 PML body
GO:0033290 eukaryotic 48S preinitiation complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000104408
View Gene Order
ENSBTAG00000006702
Not yet available
Pathways
NETPATH
REACTOME
REACT_255163
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_254308
Translation pathway
REACT_256488
Translation initiation complex formation pathway
REACT_247926
Metabolism of proteins pathway
REACT_229570
Cap-dependent Translation Initiation pathway
REACT_262064
Eukaryotic Translation Initiation pathway
REACT_249044
Formation of a pool of free 40S subunits pathway
REACT_233572
Gene Expression pathway
REACT_259469
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_236458
Ribosomal scanning and start codon recognition pathway
REACT_262078
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_249316
Formation of the ternary complex, and subsequently, the 43S complex pathway
KEGG
mmu03013
RNA transport pathway
mmu05160
Hepatitis C pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_79
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_2085
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_1979
Translation initiation complex formation pathway
REACT_1258
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_1797
Formation of a pool of free 40S subunits pathway
REACT_1079
Formation of the ternary complex, and subsequently, the 43S complex pathway
REACT_931
Ribosomal scanning and start codon recognition pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_71
Gene Expression pathway
REACT_203882
Formation of the ternary complex, and subsequently, the 43S complex pathway
REACT_246268
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_226022
Gene Expression pathway
REACT_218564
Eukaryotic Translation Initiation pathway
REACT_225918
Cap-dependent Translation Initiation pathway
REACT_216229
Formation of a pool of free 40S subunits pathway
REACT_209048
Translation pathway
REACT_202903
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_213782
Metabolism of proteins pathway
REACT_220444
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_224343
Translation initiation complex formation pathway
REACT_222420
Ribosomal scanning and start codon recognition pathway
KEGG
hsa03013
RNA transport pathway
hsa05160
Hepatitis C pathway
INOH
PID NCI
hif2pathway
HIF-2-alpha transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.289992 Mm.426227
RefSeq NM_008388
OMIM
CCDS CCDS27452
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca