Version 5.4
Mus musculus Gene: Galt
Summary
InnateDB Gene IDBG-138370.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Galt
Gene Name galactose-1-phosphate uridyl transferase
Synonyms AW553376
Species Mus musculus
Ensembl Gene ENSMUSG00000036073
Encoded Proteins
IDBP-138374
galactose-1-phosphate uridyl transferase
IDBP-265381
galactose-1-phosphate uridyl transferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000213930:
Galactose-1-phosphate uridyl transferase (GALT) catalyzes the second step of the Leloir pathway of galactose metabolism, namely the conversion of UDP-glucose + galactose-1-phosphate to glucose-1-phosphate + UDP-galactose. The absence of this enzyme results in classic galactosemia in humans and can be fatal in the newborn period if lactose is not removed from the diet. The pathophysiology of galactosemia has not been clearly defined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:41755228-41758695
Strand Forward strand
Band A5
Transcripts
ENSMUST00000084695 ENSMUSP00000081745
ENSMUST00000108038 ENSMUSP00000103673
ENSMUST00000135734
ENSMUST00000151490
ENSMUST00000132760
ENSMUST00000150908
ENSMUST00000147719
ENSMUST00000130698
ENSMUST00000154275
ENSMUST00000133106
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0008108 UDP-glucose:hexose-1-phosphate uridylyltransferase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006012 galactose metabolic process
GO:0006258 UDP-glucose catabolic process
Cellular Component
GO:0005794 Golgi apparatus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000213930
View Gene Order
ENSBTAG00000015807
Not yet available
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_257006
Galactose catabolism pathway
REACT_188937
Metabolism pathway
REACT_203949
Glycogen storage diseases pathway
REACT_203841
Myoclonic epilepsy of Lafora pathway
REACT_248571
Metabolism of carbohydrates pathway
KEGG
mmu00520
Amino sugar and nucleotide sugar metabolism pathway
mmu00052
Galactose metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_532
Galactose catabolism pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_111217
Metabolism pathway
REACT_116125
Disease pathway
REACT_200833
Glycogen storage diseases pathway
KEGG
hsa00052
Galactose metabolism pathway
hsa00520
Amino sugar and nucleotide sugar metabolism pathway
INOH
INOH website
Galactose metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.405145 Mm.439669 Mm.471285
RefSeq NM_016658
OMIM
CCDS CCDS38720
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca