Version 5.4
Mus musculus Gene: Cd14
Summary
InnateDB Gene IDBG-138525.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd14
Gene Name CD14 antigen
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000051439
Encoded Proteins
IDBP-138527
CD14 antigen
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21078886
Cd14 contributes to nucleic acid uptake in macrophages and acts as a co-receptor for endosomal Tlr7/Tlr9 activation.
InnateDB Annotation from Orthologs
Summary
PMID 19776284
[Homo sapiens] CD14 co-receptor participates with toll-like receptors (TLRs) in the response of microglial cells to fibrillar forms of beta-amyloid, contributing to microglial activation.
PMID 19840871
[Homo sapiens] CD14 recognizes necrotic cells in addition to LPS, PG, apoptotic cells, and lipids, suggesting that it might be a universal adaptor for damage-associated molecular pattern (DAMP) and pathogen-associated molecular patterns (PAMP).
PMID 10652232
[Homo sapiens] CD14 is a molecule that binds to lipopolysaccharide (LPS) and facilitates its signalling by helping TLR4-LY96 to sense and signal the presence of LPS.
PMID 21078886
[Homo sapiens] CD14 contributes to nucleic acid uptake in macrophages and acts as a co-receptor for endosomal TLR7/TLR9 activation.
PMID 23548899
[Homo sapiens] CD14 acts as an adaptor molecule for the immune recognition of salmonella curli fibers.
Entrez Gene
Summary This gene encodes a protein that plays an important role in the innate immune response and is expressed in monocyte/macrophage cells. This gene product acts as a co-receptor that binds several microbial and fungal molecules, including lipopolysaccharides (LPS). This proteins LPS-binding activity is enhanced by the LPS binding protein (LBP) to allow binding to the TLR4-MD-2 co-receptor complex. The product of this gene is found in two forms, either as a soluble protein or attached to the cell surface by a glycosylphosphatidylinositol anchor. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:36725074-36726736
Strand Reverse strand
Band B2
Transcripts
ENSMUST00000061829 ENSMUSP00000056669
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001530 lipopolysaccharide binding
GO:0005515 protein binding
GO:0070891 lipoteichoic acid binding
Biological Process
GO:0002237 response to molecule of bacterial origin
GO:0006954 inflammatory response
GO:0009408 response to heat
GO:0032026 response to magnesium ion
GO:0032496 response to lipopolysaccharide
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034612 response to tumor necrosis factor
GO:0045087 innate immune response (InnateDB)
GO:0045471 response to ethanol
GO:0045807 positive regulation of endocytosis
GO:0050715 positive regulation of cytokine secretion
GO:0051602 response to electrical stimulus
GO:0071222 cellular response to lipopolysaccharide
GO:0071223 cellular response to lipoteichoic acid
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0031225 anchored component of membrane
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000170458
View Gene Order
ENSBTAG00000015032
Not yet available
Pathways
NETPATH
REACTOME
REACT_263316
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_263004
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_239142
Innate Immune System pathway
REACT_255939
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_198539
TRAF6 mediated induction of TAK1 complex pathway
REACT_230745
Immune System pathway
REACT_254406
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_196636
TRIF-mediated programmed cell death pathway
REACT_262462
Activated TLR4 signalling pathway
REACT_226192
IKK complex recruitment mediated by RIP1 pathway
REACT_241786
MyD88-independent cascade pathway
REACT_230045
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_238546
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_240350
Transfer of LPS from LBP carrier to CD14 pathway
REACT_225463
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
REACT_246719
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
mmu04640
Hematopoietic cell lineage pathway
mmu04620
Toll-like receptor signaling pathway pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04010
MAPK signaling pathway pathway
mmu05146
Amoebiasis pathway
mmu04145
Phagosome pathway
INOH
INOH website
Toll-like receptor signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25351
TRAF6 mediated induction of TAK1 complex pathway
REACT_25374
IKK complex recruitment mediated by RIP1 pathway
REACT_25148
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
REACT_150361
TRIF-mediated programmed cell death pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_6822
Transfer of LPS from LBP carrier to CD14 pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_6900
Immune System pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04640
Hematopoietic cell lineage pathway
hsa05130
Pathogenic Escherichia coli infection pathway
hsa04010
MAPK signaling pathway pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa05146
Amoebiasis pathway
hsa04145
Phagosome pathway
INOH
INOH website
Toll-like receptor signaling pathway pathway
PID NCI
integrin1_pathway
Beta1 integrin cell surface interactions
integrin_a4b1_pathway
Alpha4 beta1 integrin signaling events
toll_endogenous_pathway
Endogenous TLR signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_009841
OMIM
CCDS CCDS29159
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca