Version 5.4
Mus musculus Gene: Hspbp1
Summary
InnateDB Gene IDBG-138595.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hspbp1
Gene Name HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
Synonyms 1500019G21Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000063802
Encoded Proteins
IDBP-138597
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21247889
Hspbp1 interacts with Pglyrp1 and inhibits the cytotoxic activity of the Hspa1a :: Pglyrp1 complex secreted by lymphocytes.
InnateDB Annotation from Orthologs
Summary
PMID 21247889
[Homo sapiens] HSPBP1 interacts with PGLYRP1 and inhibits the cytotoxic activity of the HSPA1A :: PGLYRP1 complex secreted by lymphocytes.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133265:
Gene Information
Type Protein coding
Genomic Location Chromosome 7:4660521-4684963
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000079970 ENSMUSP00000078886
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0031398 positive regulation of protein ubiquitination
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000133265
View Gene Order
ENSBTAG00000003644
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt Q99P31
TrEMBL
UniProt Splice Variant
Entrez Gene 66245
UniGene Mm.6803
RefSeq NM_024172 XM_006540288
OMIM
CCDS CCDS20740
HPRD
IMGT
MGI ID MGI:1913495
MGI Symbol Hspbp1
EMBL AF338351 AK013263 AK088469 BC014758
GenPept AAH14758 AAK11657 BAB28756 BAC40373
RNA Seq Atlas 66245

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca