Version 5.4
Mus musculus Gene: Icam1
Summary
InnateDB Gene IDBG-138668.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Icam1
Gene Name intercellular adhesion molecule 1
Synonyms CD54; Icam-1; Ly-47; MALA-2
Species Mus musculus
Ensembl Gene ENSMUSG00000037405
Encoded Proteins
IDBP-138670
intercellular adhesion molecule 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25549946
Tmem126a upregulates genes involved in antigen presentation; such as Icam1, MHC II, Cd86 and Cd40, via the Tlr4 signal transduction pathway.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 9:21015960-21028797
Strand Forward strand
Band A3
Transcripts
ENSMUST00000086399 ENSMUSP00000083587
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 5 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0032403 protein complex binding
Biological Process
GO:0001541 ovarian follicle development
GO:0001666 response to hypoxia
GO:0001975 response to amphetamine
GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO:0002438 acute inflammatory response to antigenic stimulus
GO:0002457 T cell antigen processing and presentation
GO:0002693 positive regulation of cellular extravasation
GO:0007155 cell adhesion
GO:0007159 leukocyte cell-cell adhesion
GO:0007569 cell aging
GO:0007605 sensory perception of sound
GO:0008360 regulation of cell shape
GO:0010212 response to ionizing radiation
GO:0010477 response to sulfur dioxide
GO:0014070 response to organic cyclic compound
GO:0016337 single organismal cell-cell adhesion
GO:0022614 membrane to membrane docking
GO:0030155 regulation of cell adhesion
GO:0030838 positive regulation of actin filament polymerization
GO:0031669 cellular response to nutrient levels
GO:0032321 positive regulation of Rho GTPase activity
GO:0032496 response to lipopolysaccharide
GO:0033627 cell adhesion mediated by integrin
GO:0034698 response to gonadotropin
GO:0042493 response to drug
GO:0043200 response to amino acid
GO:0044406 adhesion of symbiont to host
GO:0045087 innate immune response (InnateDB)
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045471 response to ethanol
GO:0045907 positive regulation of vasoconstriction
GO:0046688 response to copper ion
GO:0046813 receptor-mediated virion attachment to host cell
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050900 leukocyte migration
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051926 negative regulation of calcium ion transport
GO:0061028 establishment of endothelial barrier
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071222 cellular response to lipopolysaccharide
GO:0071310 cellular response to organic substance
GO:0071312 cellular response to alkaloid
GO:0071333 cellular response to glucose stimulus
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071456 cellular response to hypoxia
GO:0097368 establishment of Sertoli cell barrier
GO:1900027 regulation of ruffle assembly
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000352 negative regulation of endothelial cell apoptotic process
Cellular Component
GO:0001772 immunological synapse
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_202937
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_230745
Immune System pathway
REACT_206066
Extracellular matrix organization pathway
REACT_198660
Interferon gamma signaling pathway
REACT_198666
Interferon Signaling pathway
REACT_216309
Integrin cell surface interactions pathway
REACT_229531
Adaptive Immune System pathway
KEGG
mmu04514
Cell adhesion molecules (CAMs) pathway
mmu04650
Natural killer cell mediated cytotoxicity pathway
mmu04670
Leukocyte transendothelial migration pathway
mmu05416
Viral myocarditis pathway
mmu05150
Staphylococcus aureus infection pathway
mmu05144
Malaria pathway
mmu05143
African trypanosomiasis pathway
INOH
PID NCI
Cross-References
SwissProt P13597
TrEMBL Q3TB10 Q3U8M7 Q3UDC5
UniProt Splice Variant
Entrez Gene 15894
UniGene Mm.435508
RefSeq NM_010493
OMIM
CCDS CCDS22889
HPRD
IMGT
MGI ID MGI:96392
MGI Symbol Icam1
EMBL AK150057 AK150141 AK152155 AK171520 AK172321 CH466522 M31585 M90546 M90547 M90548 M90549 M90550 M90551 X16624 X16625 X52264 X54331
GenPept AAA37875 AAA37876 BAE29272 BAE29336 BAE30990 BAE42504 BAE42944 CAA34621 CAA34622 CAA36507 EDL25151
RNA Seq Atlas 15894

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca