Version 5.4
Mus musculus Gene: Arl5b
Summary
InnateDB Gene IDBG-138680.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arl5b
Gene Name ADP-ribosylation factor-like 5B
Synonyms 4930587A11Rik; Arl8; AW146430
Species Mus musculus
Ensembl Gene ENSMUSG00000017418
Encoded Proteins
IDBP-138682
ADP-ribosylation factor-like 5B
IDBP-138684
ADP-ribosylation factor-like 5B
IDBP-540888
ADP-ribosylation factor-like 5B
IDBP-541420
ADP-ribosylation factor-like 5B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25451939
Arl5b negatively regulates the antiviral innate immune response by binding to Ifih1 and prevents the subsequent interaction of Ifih1 to poly(I:C).
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165997:
ARL5B (ARL8) belongs to a family of proteins that are structurally similar to ADP-ribosylation factors (ARFs; see MIM 103180). ARLs and ARFs are part of the RAS superfamily of regulatory GTPases.[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:15049395-15082456
Strand Forward strand
Band A2
Transcripts
ENSMUST00000017562 ENSMUSP00000017562
ENSMUST00000069870 ENSMUSP00000069725
ENSMUST00000128682 ENSMUSP00000120178
ENSMUST00000129509 ENSMUSP00000117885
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
Biological Process
GO:0006886 intracellular protein transport
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0008150 biological_process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005575 cellular_component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000165997
View Gene Order
ENSBTAG00000043964
Not yet available
Cross-References
SwissProt
TrEMBL D6RJJ6
UniProt Splice Variant
Entrez Gene 75869
UniGene Mm.174068 Mm.412947 Mm.434282
RefSeq NM_029466
OMIM
CCDS CCDS15704
HPRD
IMGT
MGI ID MGI:1923119
MGI Symbol Arl5b
EMBL AL928632 AL929268
GenPept
RNA Seq Atlas 75869

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca