Version 5.4
| Mus musculus Gene: Hars | |||||||||||
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| Summary | |||||||||||
| InnateDB Gene | IDBG-138916.6 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | Hars | ||||||||||
| Gene Name | histidyl-tRNA synthetase | ||||||||||
| Synonyms | MMHRS | ||||||||||
| Species | Mus musculus | ||||||||||
| Ensembl Gene | ENSMUSG00000001380 | ||||||||||
| Encoded Proteins |
histidyl-tRNA synthetase
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
| Entrez Gene | |||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170445:
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] |
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| Gene Information | |||||||||||
| Type | Protein coding | ||||||||||
| Genomic Location | Chromosome 18:36766530-36783205 | ||||||||||
| Strand | Reverse strand | ||||||||||
| Band | B2 | ||||||||||
| Transcripts |
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| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||
| NETPATH | |||||||||||
| REACTOME | |||||||||||
| KEGG |
Aminoacyl-tRNA biosynthesis pathway
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| INOH | |||||||||||
| PID NCI | |||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||
| NETPATH | |||||||||||
| REACTOME |
Cytosolic tRNA aminoacylation pathway
tRNA Aminoacylation pathway
Gene Expression pathway
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| KEGG |
Aminoacyl-tRNA biosynthesis pathway
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| INOH |
Histidine degradation pathway
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| PID NCI | |||||||||||
| Cross-References | |||||||||||
| SwissProt | Q61035 | ||||||||||
| TrEMBL | |||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 15115 | ||||||||||
| UniGene | Mm.10528 Mm.410049 | ||||||||||
| RefSeq | NM_008214 | ||||||||||
| OMIM | |||||||||||
| CCDS | CCDS29164 | ||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| MGI ID | MGI:108087 | ||||||||||
| MGI Symbol | Hars | ||||||||||
| EMBL | AK146922 AK166826 AK166892 U39473 | ||||||||||
| GenPept | AAC52914 BAE27533 BAE39050 BAE39097 | ||||||||||
| RNA Seq Atlas | 15115 | ||||||||||