InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Patz1

Summary

InnateDB Gene

IDBG-138937.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Patz1

Gene Name

POZ (BTB) and AT hook containing zinc finger 1

Synonyms

8430401L15Rik; AI447519; Mazr; Patz; Zfp278

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020453

Encoded Proteins

IDBP-138941

POZ (BTB) and AT hook containing zinc finger 1

IDBP-138943

POZ (BTB) and AT hook containing zinc finger 1

IDBP-138945

POZ (BTB) and AT hook containing zinc finger 1

IDBP-261108

POZ (BTB) and AT hook containing zinc finger 1

IDBP-789413

POZ (BTB) and AT hook containing zinc finger 1

IDBP-542146

POZ (BTB) and AT hook containing zinc finger 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100105:
The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:3288874-3309083

Strand

Forward strand

Band

Transcripts

ENSMUST00000101644
ENSMUST00000057089	ENSMUSP00000050684
ENSMUST00000093402	ENSMUSP00000091103
ENSMUST00000094471	ENSMUSP00000092043
ENSMUST00000110043	ENSMUSP00000105670
ENSMUST00000142561
ENSMUST00000144396
ENSMUST00000134089	ENSMUSP00000138522
ENSMUST00000123983
ENSMUST00000153603
ENSMUST00000136285
ENSMUST00000154319	ENSMUSP00000122832

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0007283	spermatogenesis
GO:0008584	male gonad development
GO:0010468	regulation of gene expression
GO:0030217	T cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000100105

View Gene Order

ENSBTAG00000005478

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_2

AndrogenReceptor pathway

REACTOME

KEGG

INOH

PID NCI

ar_pathway

Coregulation of Androgen receptor activity

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.486715

RefSeq

NM_001253690 NM_019574

OMIM

CCDS

CCDS24356 CCDS56754

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas