InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hars2

Summary

InnateDB Gene

IDBG-139068.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hars2

Gene Name

histidyl-tRNA synthetase 2, mitochondrial (putative)

Synonyms

4631412B19Rik; AI593507; Harsl; HARSR; HO3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000019143

Encoded Proteins

IDBP-139070

histidyl-tRNA synthetase 2, mitochondrial (putative)

IDBP-536114

histidyl-tRNA synthetase 2, mitochondrial (putative)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112855:
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes share a bidirectional promoter. [provided by RefSeq, Jul 2008]
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes likely share a bidirectional promoter. Mutations in this gene are associated with the pathogenesis of Perrault syndrome, which involves ovarian dysgenesis and sensorineural hearing loss. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:36783008-36792562

Strand

Forward strand

Band

Transcripts

ENSMUST00000019287	ENSMUSP00000019287
ENSMUST00000152954	ENSMUSP00000117231
ENSMUST00000134122
ENSMUST00000145876
ENSMUST00000131952
ENSMUST00000155842
ENSMUST00000124204

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004812	aminoacyl-tRNA ligase activity
GO:0004821	histidine-tRNA ligase activity
GO:0005524	ATP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006418	tRNA aminoacylation for protein translation
GO:0006427	histidyl-tRNA aminoacylation
GO:0008152	metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000112855

View Gene Order

ENSBTAG00000025212

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu00970

Aminoacyl-tRNA biosynthesis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_15302

Mitochondrial tRNA aminoacylation pathway

REACT_15482

tRNA Aminoacylation pathway

REACT_71

Gene Expression pathway

KEGG

hsa00970

Aminoacyl-tRNA biosynthesis pathway

INOH

INOH website

Histidine degradation pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.282700 Mm.407814

RefSeq

NM_080636 XM_006526238 XM_006526239 XM_006526240

OMIM

CCDS

CCDS29165

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas