InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Aldh5a1

Summary

InnateDB Gene

IDBG-139284.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aldh5a1

Gene Name

aldhehyde dehydrogenase family 5, subfamily A1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000035936

Encoded Proteins

IDBP-139286

aldhehyde dehydrogenase family 5, subfamily A1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112294:
This protein belongs to the aldehyde dehydrogenase family of proteins. This gene encodes a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, is a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA). In response to the defect, physiologic fluids from patients accumulate GHB, a compound with numerous neuromodulatory properties. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:24907579-24937661

Strand

Reverse strand

Band

A3.1

Transcripts

ENSMUST00000037615

ENSMUSP00000040591

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004777	succinate-semialdehyde dehydrogenase (NAD+) activity
GO:0009013	succinate-semialdehyde dehydrogenase [NAD(P)+] activity
GO:0016491	oxidoreductase activity

Biological Process

GO:0006006	glucose metabolic process
GO:0006083	acetate metabolic process
GO:0006105	succinate metabolic process
GO:0006536	glutamate metabolic process
GO:0006541	glutamine metabolic process
GO:0006650	glycerophospholipid metabolic process
GO:0006678	glucosylceramide metabolic process
GO:0006681	galactosylceramide metabolic process
GO:0006749	glutathione metabolic process
GO:0007417	central nervous system development
GO:0008152	metabolic process
GO:0009448	gamma-aminobutyric acid metabolic process
GO:0009450	gamma-aminobutyric acid catabolic process
GO:0009791	post-embryonic development
GO:0022904	respiratory electron transport chain
GO:0042135	neurotransmitter catabolic process
GO:0046459	short-chain fatty acid metabolic process
GO:0051289	protein homotetramerization
GO:0055114	oxidation-reduction process