Version 5.4
Mus musculus Gene: P2rx6
Summary
InnateDB Gene IDBG-139432.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol P2rx6
Gene Name purinergic receptor P2X, ligand-gated ion channel, 6
Synonyms P2rxl1; P2x6; P2xm
Species Mus musculus
Ensembl Gene ENSMUSG00000022758
Encoded Proteins
IDBP-139434
purinergic receptor P2X, ligand-gated ion channel, 6
IDBP-625459
purinergic receptor P2X, ligand-gated ion channel, 6
IDBP-625464
purinergic receptor P2X, ligand-gated ion channel, 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000099957:
The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:17561885-17577800
Strand Forward strand
Band A3
Transcripts
ENSMUST00000023441 ENSMUSP00000023441
ENSMUST00000171002 ENSMUSP00000132727
ENSMUST00000168383 ENSMUSP00000130079
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001614 purinergic nucleotide receptor activity
GO:0004931 extracellular ATP-gated cation channel activity
GO:0005216 ion channel activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0042802 identical protein binding
Biological Process
GO:0006811 ion transport
GO:0006812 cation transport
GO:0034220 ion transmembrane transport
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0051260 protein homooligomerization
GO:0051291 protein heterooligomerization
Cellular Component
GO:0005639 integral component of nuclear inner membrane
GO:0005737 cytoplasm
GO:0005887 integral component of plasma membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030054 cell junction
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000099957
View Gene Order
ENSBTAG00000019244
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04020
Calcium signaling pathway pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04020
Calcium signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9Q857
UniProt Splice Variant
Entrez Gene 18440
UniGene Mm.483836 Mm.8032
RefSeq NM_001159561 NM_011028
OMIM
CCDS CCDS28007 CCDS49778
HPRD
IMGT
MGI ID MGI:1337113
MGI Symbol P2rx6
EMBL AC115733
GenPept
RNA Seq Atlas 18440

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca