InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LATS2

Summary

InnateDB Gene

IDBG-13987.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LATS2

Gene Name

LATS, large tumor suppressor, homolog 2 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000150457

Encoded Proteins

IDBP-13989

LATS, large tumor suppressor, homolog 2 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:20973032-21061547

Strand

Reverse strand

Band

q12.11

Transcripts

ENST00000382592	ENSP00000372035
ENST00000472754

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 168 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	168 [view]
Protein-Protein	167 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0006468	protein phosphorylation
GO:0007067	mitotic nuclear division
GO:0009755	hormone-mediated signaling pathway
GO:0030216	keratinocyte differentiation
GO:0034613	cellular protein localization
GO:0035329	hippo signaling
GO:0035556	intracellular signal transduction
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0046620	regulation of organ growth
GO:0090090	negative regulation of canonical Wnt signaling pathway

Cellular Component

GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005815	microtubule organizing center
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000021959

View Gene Order

ENSBTAG00000014406

Not yet available

Pathways

NETPATH

REACTOME

REACT_118607

Signaling by Hippo pathway

REACT_111102

Signal Transduction pathway

KEGG

INOH

PID NCI

ar_pathway

Coregulation of Androgen receptor activity

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.644552 Hs.78960

RefSeq

NM_014572 XM_005266342

HUGO

OMIM

CCDS

CCDS9294

HPRD

07277

IMGT

EMBL

GenPept

RNA Seq Atlas