Version 5.4
Mus musculus Gene: Slc22a8
Summary
InnateDB Gene IDBG-140196.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc22a8
Gene Name solute carrier family 22 (organic anion transporter), member 8
Synonyms Oat3; Roct
Species Mus musculus
Ensembl Gene ENSMUSG00000063796
Encoded Proteins
IDBP-140198
solute carrier family 22 (organic anion transporter), member 8
IDBP-619896
solute carrier family 22 (organic anion transporter), member 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149452:
This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:8591254-8611834
Strand Forward strand
Band A
Transcripts
ENSMUST00000010251 ENSMUSP00000010251
ENSMUST00000170817 ENSMUSP00000131045
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005080 protein kinase C binding
GO:0005452 inorganic anion exchanger activity
GO:0008514 organic anion transmembrane transporter activity
GO:0015075 ion transmembrane transporter activity
GO:0015651 quaternary ammonium group transmembrane transporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0009636 response to toxic substance
GO:0015697 quaternary ammonium group transport
GO:0031427 response to methotrexate
GO:0034220 ion transmembrane transport
GO:0034635 glutathione transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000149452
View Gene Order
ENSBTAG00000013644
Not yet available
Pathways
NETPATH
REACTOME
REACT_217615
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_247550
SLC-mediated transmembrane transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_198609
Organic cation/anion/zwitterion transport pathway
REACT_198604
Organic anion transport pathway
KEGG
mmu04976
Bile secretion pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22310
Organic anion transport pathway
REACT_19305
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_22345
Organic cation/anion/zwitterion transport pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
hsa04976
Bile secretion pathway
INOH
PID NCI
Cross-References
SwissProt O88909
TrEMBL
UniProt Splice Variant
Entrez Gene 19879
UniGene Mm.285294
RefSeq NM_001164634 NM_001164635 NM_031194
OMIM
CCDS CCDS29537
HPRD
IMGT
MGI ID MGI:1336187
MGI Symbol Slc22a8
EMBL AB079895 AF078869 AK031962 AK044336 AK157891 BC014762
GenPept AAC61265 AAH14762 BAC27624 BAC31873 BAC53618 BAE34249
RNA Seq Atlas 19879

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca