InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ephb6

Summary

InnateDB Gene

IDBG-140762.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ephb6

Gene Name

Eph receptor B6

Synonyms

Cekl; Mep

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029869

Encoded Proteins

IDBP-251141

Eph receptor B6

IDBP-626778

Eph receptor B6

IDBP-626779

Eph receptor B6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106123:
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ephrin receptor encoded by this gene lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands. [provided by RefSeq, Jul 2008]
This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:41605482-41620509

Strand

Forward strand

Band

B2.1

Transcripts

ENSMUST00000114732	ENSMUSP00000110380
ENSMUST00000170624
ENSMUST00000167082	ENSMUSP00000133131
ENSMUST00000167497	ENSMUSP00000132773

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005003	ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0035898	parathyroid hormone secretion
GO:0048013	ephrin receptor signaling pathway
GO:0055074	calcium ion homeostasis

Cellular Component

GO:0005576	extracellular region
GO:0005887	integral component of plasma membrane

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000106123

View Gene Order

Pathways

NETPATH

REACTOME

REACT_243590

EPH-ephrin mediated repulsion of cells pathway

REACT_258158

EPH-Ephrin signaling pathway

REACT_257656

EPHB-mediated forward signaling pathway

REACT_261444

Axon guidance pathway

REACT_188576

Developmental Biology pathway

REACT_241951

Ephrin signaling pathway

KEGG

mmu04360

Axon guidance pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04360

Axon guidance pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.271976

RefSeq

NM_001146351 NM_007680

OMIM

CCDS

CCDS20051

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas